Synthesis of substituted aryl enol ethers

CuI-Mediated Synthesis of Sulfonyl Benzofuran-3-ones and Chroman-4-ones

“…Copper-mediated cyclization reactions that use prefunctionalized substrates for the rapid and efficient construction of structurally diverse benzo-fused heterocyclic frameworks have been recognized as cost-effective alternatives to classic protocols that involve palladium-mediated C–H activation systems . In most copper-mediated chemical bond forming reactions, however, the focus has been on the formation of only one carbon–carbon (C–C) or carbon–heteroatom (C–N, C–O, or C–S for Ullmann-type reactions) bond. In contrast, cascade reactions are highly efficient for forming multiple bonds in a one-pot procedure.…”