Synthesis of Substituted Aryl Incorporated Oxazolo[4,5-b]Pyridine-Triazole Derivatives: Anticancer Evaluation and Molecular Docking Studies

Sireesha, Reddymasu; Tej, Mandava Bhuvan; Nuthalapati, Poojith; Sreenivasulu, Reddymasu; Musuluri, Murali; Subbarao, M. V.

doi:10.1080/10406638.2021.2021256

Cited by 20 publications

(4 citation statements)

References 74 publications

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“…Yet, the first bioactivity (anthelmintic and acaricidal activity) of compounds with oxazolopyridine moiety, namely oxazolo [4,5-b]pyridine, was reported nearly 20 years later by Rüfenacht et al, and then, oxazolo [5,4-b] Fused Pyridine Derivatives: Synthesis and Biological Activities DOI: http://dx.doi.org/10.5772/intechopen.107537 pyridine-bearing compounds were reported having carrageenan rat foot edema assay activity by Clark et al [118,119]. Later, antimicrobial, anti-infective, antiviral, and antiproliferative activities of several compounds having oxazololopyridine moiety were reported [120][121][122][123][124].…”

Section: Oxazolopyridines Isoxazolopyridines and Oxadiazolopyridinesmentioning

confidence: 99%

Fused Pyridine Derivatives: Synthesis and Biological Activities

Istanbullu¹,

Bayraktar²,

Saylam³

2023

Exploring Chemistry With Pyridine Derivatives

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Five-membered heteroaromatic ring fused pyridine derivatives are of increasing interest in drug design and medicinal chemistry. The structural similarity of many drugs (especially antiviral and anticancer ones) with DNA bases such as adenine and guanine is a key factor to explain their effectiveness. Apart from these, it is also found in the structures of substances with antituberculosis, antibacterial, antifungal, anti-inflammatory, and antimalarial activities. Another advantage of this group of compounds is their positive contribution to solubility, polarity, lipophilicity, and hydrogen bonding capacity properties of the compounds they are incorporated into. In this chapter, various bioactivities of fused pyridine derivatives will be categorized and summarized.

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Section: Oxazolopyridines Isoxazolopyridines and Oxadiazolopyridinesmentioning

confidence: 99%

Fused Pyridine Derivatives: Synthesis and Biological Activities

Istanbullu¹,

Bayraktar²,

Saylam³

2023

Exploring Chemistry With Pyridine Derivatives

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“…This possible peripheral vasodilation causes a baroreceptor-mediated increase in sympathetic tone, which mitigates the DHPs' negative inotropic action. In patients with heart failure and systolic dysfunction, it is recommended to avoid and use calcium channel blockers [non-dihydropyridines] with negative inotropic effects with caution [124]. Verapamil and diltiazem, unlike DHPs, lower the sinoatrial (SA) node conduction rate (negative chronotropes) and slow atrioventricular (AV) conduction (negative chromotropes) [125].…”

Section: Regulation Of Voltage-gated Calcium (Ca V ) Ion Channel By P...mentioning

confidence: 99%

“…Yet, the first bioactivity (anthelmintic and acaricidal activity) of compounds with oxazolopyridine moiety, namely oxazolo [4,5-b] pyridine-bearing compounds were reported having carrageenan rat foot edema assay activity by Clark et al [118,119]. Later, antimicrobial, anti-infective, antiviral, and antiproliferative activities of several compounds having oxazololopyridine moiety were reported [120][121][122][123][124].…”

Section: Oxazolopyridines Isoxazolopyridines and Oxadiazolopyridinesmentioning

confidence: 99%

Exploring Chemistry with Pyridine Derivatives

2023

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“…The majority of 1,2,3‐triazole‐benzoxazole hybrids only showed weak to moderate antiproliferative activity against breast cancer cell lines, [ 44,45 ] whereas 1,2,3‐triazole‐pyrimidine‐oxazolo[4,5‐ b ]pyridine hybrids 23 (IC 50 : 0.045–13.2 µM, MTT assay) exhibited promising activity against MCF‐7 breast cancer cells. [ 46 ] The SAR illustrated that electron‐donating group especially methoxy group was beneficial for the activity. In particular, hybrids 23a,b (IC 50 : 45 and 120 nM) were 46.8 and 17.…”

Section: 23‐triazole‐azole Hybridsmentioning

confidence: 99%

The anti‐breast cancer therapeutic potential of 1,2,3‐triazole‐containing hybrids

Song,

Zhang,

Zhang

et al. 2023

Archiv der Pharmazie

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Breast cancer, as one of the most common invasive malignancies and the leading cause of cancer‐related deaths in women globally, poses a significant challenge in the world health system. Substantial advances in diagnosis and treatment have significantly improved the survival rate of breast cancer patients, but the number of incidences and deaths of breast cancer are projected to increase by 40% and 50%, respectively, by 2040. Chemotherapy is one of the principal treatments for breast cancer therapy, but multidrug resistance and severe side effects remain the major obstacles to the success of treatment. Hence, there is a vital need to develop novel chemotherapeutic agents to combat this deadly disease. 1,2,3‐Triazole, which can be effectively constructed by click chemistry, not only can serve as a linker to connect different anti‐breast cancer pharmacophores but also is a valuable pharmacophore with anti‐breast cancer potential and favorable properties such as hydrogen bonding, moderate dipole moment, and enhanced water solubility. Particularly, 1,2,3‐triazole‐containing hybrids have demonstrated promising in vitro and in vivo anti‐breast cancer potential against both drug‐sensitive and drug‐resistant forms and possessed excellent selectivity by targeting different biological pathways associated with breast cancer, representing privileged scaffolds for the discovery of novel anti‐breast cancer candidates. This review concentrates on the latest advancements of 1,2,3‐triazole‐containing hybrids with anti‐breast cancer potential, including work published between 2020 and the present. The structure–activity relationships (SARs) and mechanisms of action are also reviewed to shed light on the development of more effective and multitargeted candidates.

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Synthesis of Substituted Aryl Incorporated Oxazolo[4,5-b]Pyridine-Triazole Derivatives: Anticancer Evaluation and Molecular Docking Studies

Cited by 20 publications

References 74 publications

Fused Pyridine Derivatives: Synthesis and Biological Activities

Fused Pyridine Derivatives: Synthesis and Biological Activities

Exploring Chemistry with Pyridine Derivatives

The anti‐breast cancer therapeutic potential of 1,2,3‐triazole‐containing hybrids

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