Synthesis of (substituted benzamidostyryl) lH-benzimidazoles and their screening for anti-inflammatory activity

Abstract

A series of substituted (benzamidostyryl) benzimidazole (3a-r) were synthesized and evaluated for their possible anti-inflammatory and ulcerogenicity. The structures of the synthesized compounds were confirmed on the basis of their spectral data and elemental analysis. Majority of the compounds were active in carrageenaninduced hind paw edema method test and compounds 3b, 3k had shown high potency after 3 and 4 h time intervals (P \ 0.001) almost equipotent to the standard drug indomethacin and showed less severity index than it.

Synthesis and characterization of a novel drug-loaded polymer, poly(lactic acid-co-aminomethyl benzimidazole)

“…anticancer, antifungal, antiviral, anti-inflammatory, etc. [5][6][7][8][9][10][11][12][13]. Among them, many drug molecules have a basic skeleton of aminomethyl benzimidazole (AMB) (Figure 1).…”

“…Among them, many drug molecules have a basic skeleton of aminomethyl benzimidazole (AMB) (Figure 1). [8][9][10][11][12][13] Due to good physical properties, biocompatibility and biodegradability, polylactic acid (PLA) as an environment friendly polymer produced from renewable resource [14][15][16][17] can be used in general polymer field as packaging materials, plastic profiles, thin films, nonwovens, and clothing fibers. [18][19][20][21][22][23] Of course, for the cost reason, PLA materials are more widely used in the biomedical field as bone material, surgical sutures, eye filler, gauze dressings, drug delivery, artificial urethra, and artificial esophagus.…”

One pot synthesis of 1-((1-aryl-1H-1,2,3-triazol-4-yl)methyl)-1H-benzo[d] imidazoles in ionic liquids: Evaluation of antioxidant and antimicrobial activities

“…The benzimidazole has been an important pharmacophore and privileged structure, encompassing a diverse range of their biological properties [1,2]. Benzimidazoles have been reported as antimicrobial [3][4][5][6][7][8][9][10], antiviral [11][12][13][14], antioxidant [15], anti-inflammatory [16,17], antitumor [18] and anticancer agents [19][20][21]. 1,2,3-Triazoles due to their exclusive chemical and structural properties, have acknowledged a lot of awareness over the past decades and found extensive applications in medicinal chemistry [22][23][24][25], biological activities such as anti-HIV [27] and antimicrobial [27,28].…”

N-[1-(1H-Benzimidazol-2-yl)-2-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)vinyl]benzamide

“…The benzimidazole ring, containing two nitrogen atoms, plays an important role in the constitution of many of the natural products as well as synthetic compounds. Benzimidazole derivatives possess various pharmacological activities including antibacterial [1], anti-fungal [2], antiviral [3], antiparasitic [4], antiprotozoal [5], antihelmintic [6], anti-inflammatory [7] anti-ulcer [8], anti-hypertensive [9], anticonvulsant [10] and CNS activity [11].…”