Synthesis of [<sup>13</sup>C<sub>2</sub>]nifedipine

Ohtaka, Kuniaki; Kajiwara, Masahiro

doi:10.1002/jlcr.777

Cited by 5 publications

(1 citation statement)

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“…1.1 13 C 4 -乙酰乙酸酯的合成讨论当前报道的 13 C 标记的乙酰乙酸酯的合成方法有克莱森缩合法(Scheme 2, A) [21][22] 、克莱森缩合改进法 (Scheme 2, B) [23] 、丙二酸法(Scheme 2, C) [24] 、双烯酮法 (Scheme 2, D) [19] 以及乙酰咪唑的克莱森缩合酯化法 (Scheme 2, E) [20] . 克莱森缩合法和丙二酸法产率较低, 仅为 65%; 双烯酮法受到 13 [25] 、醋酸铵 [26][27] 、氨水 [28][29][30] 、碳酸铵 [31] 、碳酸氢铵 [32] 、氨基甲酸铵 [33] 等.…”

Section: 结果与讨论unclassified

Synthesis of Stable Isotope Labeled ¹³C₄-1,4-Dihydropyridines on 5,6-Position and Its Substituent Carbon

Hu¹,

Quan²,

Wang³

et al. 2021

Chinese Journal of Organic Chemistry

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Section: 结果与讨论unclassified

Synthesis of Stable Isotope Labeled ¹³C₄-1,4-Dihydropyridines on 5,6-Position and Its Substituent Carbon

Hu¹,

Quan²,

Wang³

et al. 2021

Chinese Journal of Organic Chemistry

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¹³C‐Labeling as a Method in Organic Synthesis, Catalysis and Biochemical Applications

Rodygin,

Bogachenkov,

Gyrdymova

et al. 2024

Chemistry Methods

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The incorporation of a labeled 13C atom provides a plethora of opportunities in organic synthesis and catalysis. Structure of complicated compounds can be successfully confirmed using the precise location of a labeled carbon atom; a reaction mechanism can be supported by the presence or absence of a label in reaction products; metabolic pathways of biological compounds can be found out depending on labeled products; the concentration of analyzed labeled compounds can be significantly lower for recording and successful interpretation of NMR spectra, etc. This review aims to provide a researcher with common and promising strategies for the synthesis of labeled compounds so that a researcher can select an appropriate route to save valuable labeled material. All the labeling approaches were considered based on starting labeling source. Ideological aim of the review is to demonstrate the opportunities for label incorporation so that a researcher can find the improvements in his own topic using labeled compounds. Utilization of labeled compounds in catalysis and studying reaction mechanisms were also considered to demonstrate the capabilities of labeled compounds, which may be useful in specific tasks and applications. The potential of labeled compounds in bioactive compound metabolite analysis was demonstrated on selected examples.

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1,4‐Dihydropyridines (DHPs) – a class of very potent drugs: syntheses of isotopically labeled DHP derivatives during the last four decades

Pleiß

2007

Labelled Comp Radiopharmac

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1,4‐Dihydropyridines (DHPs) belonging to the group of calcium antagonists or calcium channel blockers' are among the most important drugs used in the treatment of cardiovascular diseases. During the development processes all candidates on the market have to be labeled with isotopes. Since the discovery of 1,4‐dihydropyridines (DHP) as cardiovascular drugs, the published syntheses for the labeling with radioactive isotopes like tritium, carbon‐11, carbon‐14, iodine‐125 and stable isotopes like deuterium and carbon‐13 are reviewed in the present report. The different synthetic routes are depicted and the synthesis details will be discussed with respect to the yields referred to labeled starting materials, specific activities and labeling degrees. Copyright © 2007 John Wiley & Sons, Ltd.

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Synthesis of [¹³C₂]nifedipine

Abstract: Summary

Cited by 5 publications

References 4 publications

Synthesis of Stable Isotope Labeled ¹³C₄-1,4-Dihydropyridines on 5,6-Position and Its Substituent Carbon

Synthesis of Stable Isotope Labeled ¹³C₄-1,4-Dihydropyridines on 5,6-Position and Its Substituent Carbon

¹³C‐Labeling as a Method in Organic Synthesis, Catalysis and Biochemical Applications

1,4‐Dihydropyridines (DHPs) – a class of very potent drugs: syntheses of isotopically labeled DHP derivatives during the last four decades

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Synthesis of [13C2]nifedipine

Abstract: Summary

Cited by 5 publications

References 4 publications

Synthesis of Stable Isotope Labeled 13C4-1,4-Dihydropyridines on 5,6-Position and Its Substituent Carbon

Synthesis of Stable Isotope Labeled 13C4-1,4-Dihydropyridines on 5,6-Position and Its Substituent Carbon

13C‐Labeling as a Method in Organic Synthesis, Catalysis and Biochemical Applications

1,4‐Dihydropyridines (DHPs) – a class of very potent drugs: syntheses of isotopically labeled DHP derivatives during the last four decades

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Synthesis of [¹³C₂]nifedipine

Synthesis of Stable Isotope Labeled ¹³C₄-1,4-Dihydropyridines on 5,6-Position and Its Substituent Carbon

Synthesis of Stable Isotope Labeled ¹³C₄-1,4-Dihydropyridines on 5,6-Position and Its Substituent Carbon

¹³C‐Labeling as a Method in Organic Synthesis, Catalysis and Biochemical Applications