Synthesis of Symmetric Chiral Aminophenol Compounds

Abstract

In this paper, 1,6-hexamethylenediamine and p-phenylenediamine were selected to react respectively with commercially available L-valine to obtain the desired symmetrical aminophenol compounds. The structures of the aminophenol and the corresponding intermediate were characterized by high resolution mass spectrometry, nuclear magnetic resonance spectroscopy. In addition, a single crystal of compound 2A and 7B-1were obtained by recrystallization, and their structures were determined by x-ray analysis.