Synthesis of symmetrically trisubstituted benzene derivatives

Abstract

Syntheses are described of 1.3.5-trisubstituted benzenes with the following substituents CH,CI, CH,OEt, CH,OB,, and [CH,],X (X = OH, OAc, OCB,, CI, Br, CN, or C0,H). an improved route to 1,3,5-tris(hydroxymethyl)benzene and alternative routes to the corresponding tri-aldehyde and tris( bromomethyl) derivative. Strathclyde, GlasgowTHE symmetrically t risubst it ut ed benzene derivatives described here were required by Professor M. Gordon

Multiple Hydrogen Bonds in Pyridine-2,6-dimethanol and Benzene-1,3,5-trimethanol

“…Experimental Compound (I) was obtained from Aldrich. Compound (II) was prepared by reduction of trimethyl 1,3,5-benzenetricarboxylate (Cochrane, Pauson & Stevens, 1968;Storck & Manecke, 1975). Crystals of (I) and (II) suitable for singlecrystal diffraction analysis were grown by slow evaporation of methanol solutions.…”

Synthesis of a Macrobicycle Incorporating the Tris(pyrazolyl)methane Ligand

“…22 Accordingly (Scheme 5), Tpm 15 was reacted with 1,3,5-tris(bromomethyl)benzene 16 23 under high dilution conditions in DMF at 55°C, using K 2 CO 3 as the base. After chromatography (silicagel, CH 2 Cl 2 ) and crystallization from CH 2 Cl 2 / heptane, macrobicycle 2 was obtained in 28% yield as colorless crystals.…”

Synthesis and Study of A Molecular Fluorescent Chemosensor For Potassium

“…α,α',α''-Trichloromesitylene [14] and 1,3,5-benzenetriacetonitrile [15] were synthesized according to literature methods. -Infrared spectra were measured using a Mattson Instruments Cygnus 100 FTIR.…”