Synthesis of Tellurium Oxide (TeO2) Nanorods and Nanoflakes and Evaluation of Its Efficacy Against Leishmania major In Vitro and In Vivo

Tavakoli, Pooya; Ghaffarifar, Fatemeh; Delavari, Hamid; KarimiPourSaryazdi, Amir; Dayer, Mohammad Saaid; Nasiri, Vahid; Ahmadi, Salimeh

doi:10.1007/s11686-021-00445-w

Cited by 8 publications

(4 citation statements)

References 39 publications

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“…Another tellurium application is in medicine and has traditionally been exploited as an antimicrobial agent in treating some infectious diseases, including leprosy, tuberculosis, dermatitis, cystitis, and severe eye infections [153]. Tellurium is also used in labeling, imaging, and targeted drug delivery systems and has some anti-inflammatory, anti-fungal, anti-leishmaniasis, and immunomodulatory activities [154][155][156][157][158][159]. Exposure to a high amount of tellurium can cause several health issues, such as respiratory irritation, headache, drowsiness, weakness, malaise, lassitude, gastrointestinal symptoms, dizziness, and dermatitis [160].…”

Section: Telluriummentioning

confidence: 99%

Use of Microbial Consortia in Bioremediation of Metalloid Polluted Environments

et al. 2023

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Metalloids are released into the environment due to the erosion of the rocks or anthropogenic activities, causing problems for human health in different world regions. Meanwhile, microorganisms with different mechanisms to tolerate and detoxify metalloid contaminants have an essential role in reducing risks. In this review, we first define metalloids and bioremediation methods and examine the ecology and biodiversity of microorganisms in areas contaminated with these metalloids. Then we studied the genes and proteins involved in the tolerance, transport, uptake, and reduction of these metalloids. Most of these studies focused on a single metalloid and co-contamination of multiple pollutants were poorly discussed in the literature. Furthermore, microbial communication within consortia was rarely explored. Finally, we summarized the microbial relationships between microorganisms in consortia and biofilms to remove one or more contaminants. Therefore, this review article contains valuable information about microbial consortia and their mechanisms in the bioremediation of metalloids.

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Section: Telluriummentioning

confidence: 99%

Use of Microbial Consortia in Bioremediation of Metalloid Polluted Environments

et al. 2023

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“…Recently, multiple studies reported that a number of novel nanomaterial such as magnesium oxide, and iron oxide have potent anti-leishmanial effects ( 11 – 12 ). Apart from this, the therapeutic effects of many of the plants extracts like Aloe-emodin , Artemisia aucheri , Sambucus ebulus and Thymus migricus on cutaneous leishmaniasis have been conducted previously ( 13 – 15 ).…”

Section: Introductionmentioning

confidence: 99%

In Vitro Activity of Green Synthesized Silver Nanoparticles via Thymus Vulgaris Extract against Leishmania major

Zaki,

Mohammadi,

Karimipoursaryazdi

et al. 2023

IJPA

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Background: We aimed to assess the in vitro effects of the green synthesized silver nanoparticles (Ag NPs) via Thymus vulgaris (thyme) against Leishmania major infection. Methods: We have prepared T. vulgalis silver nanoparticles (TSNPs) by adding thyme extract to the silver nitrate aqueous solution (0.2 mM), and evaluated their antileishmanial activity. The viability of L. major promastigotes was assessed in the presence of various concentrations of TSNPs by direct counting after 24 h. The MTT assay was used to identify the viability of promastigotes. The same procedures were assessed in uninfected macrophage cells. The apoptotic effects of nanoparticles on L. major promastigotes were determined by flow cytometry assay using annexin staining. To evaluate anti-amastigotes activity of TSNPs, light microscopic observation was used to determine the number of parasites within the macrophages in each well. Results: The effect of TSNPs on promastigotes and amastigotes of L. major was effective and had a reverse relationship with its concentration. TSNPs, inhibited the growth rate of L. major amastigotes and, the IC50 value of these nanoparticles was estimated 3.02 µg/mL (28 µM) after 72h. The results of flow cytometry showed that the toxic effects of TSNPs on promastigotes after 24 hours were statistically significant (P<0.05) and showed 69.51% of apoptosis. Conclusion: TSNPs had an inhibitor effect on promastigote and amastigote forms of L. major in vitro. It might be considered as a candidate for the treatment of this infection.

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“…The current CL treatment strategies include the administration of antimony-based drugs, Glucantime, Paromomycin, and Miltefosine [ 9 ]. However, these compounds are associated with a number of adverse effects that limits their usage, like systemic side effects, toxicities, drug resistance, and painful injections which leads to a reduction in patient acceptance [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Antiparasitic effect of Farnesol against Leishmania major: A rationale from in vitro and in silico investigations

Sharma,

Sehgal,

Shekhar

et al. 2023

PLoS ONE

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Leishmaniasis is a vector-borne parasitic infection caused by the infective bite of female Phlebotomine sandflies. Treatment of leishmaniasis by conventional synthetic compounds is met by challenges pertaining to adverse effects which call for the discovery of newer anti-leishmanial molecules. This study was performed to evaluate the effect and modes of action of a sesquiterpene alcoholic molecule Farnesol on Leishmania major, the causative agent of Zoonotic CL. The cytotoxic effect of Farnesol against L.major promastigotes, amastigotes and macrophages was assessed by MTT test and counting. The IC50 on promastigotes by Farnesol on L.major was also evaluated by flow cytometry. In the findings, promastigotes were reduced at 167μM. The mean numbers of L.major amastigotes in macrophages were significantly decreased on exposure to Farnesol at 172μM. In addition, Farnesol induced significant apoptosis dose-dependent on L.major promastigotes. In silico protein-ligand_binding analyses indicated the effect of Farnesol in perturbation of the ergosterol synthesis pathway of Leishmania with attributes suggesting inhibition of Lanosterol-α-demethylase, the terminal enzyme of ergosterol synthesis machinery. Findings from flow cytometry reveal the role of Farnesol in apoptosis-induced killing in promastigotes. Farnesol was effective at very lower concentrations when compared to Paromomycin. Further studies are crucial to evaluate the therapeutic potential of Farnesol alone or in combination with other conventional drugs in animal models.

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Synthesis of Tellurium Oxide (TeO2) Nanorods and Nanoflakes and Evaluation of Its Efficacy Against Leishmania major In Vitro and In Vivo

Cited by 8 publications

References 39 publications

Use of Microbial Consortia in Bioremediation of Metalloid Polluted Environments

Use of Microbial Consortia in Bioremediation of Metalloid Polluted Environments

In Vitro Activity of Green Synthesized Silver Nanoparticles via Thymus Vulgaris Extract against Leishmania major

Antiparasitic effect of Farnesol against Leishmania major: A rationale from in vitro and in silico investigations

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