Synthesis of tetraalkoxyaryldihydrobenzo[g]indazoles from metabolites of dill and parsley seeds essential oil

Varakutin, Alexander E.; Shinkarev, Ilia Yu; Muravsky, Egor A.; Nasyrova, Darina I.; Samigullina, Aida I.; Semenova, Marina N.; Семенов, В. В.

doi:10.1016/j.tet.2023.133365

Tetrahedron

2023

DOI: 10.1016/j.tet.2023.133365

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Synthesis of tetraalkoxyaryldihydrobenzo[g]indazoles from metabolites of dill and parsley seeds essential oil

Alexander E. Varakutin

Ilia Yu Shinkarev

Egor A. Muravsky

et al.

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2024

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Cited by 2 publications

References 20 publications

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Synthesis of Methoxy Analogues of Coenzyme Q10 Metabolites from Parsley Seed Extracts via Baeyer–Villiger Rearrangement of Carbonyl-Substituted Polyalkoxybenzenes

Semenov,

Demchuk,

Adaeva

et al. 2024

Synthesis

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Based on the parsley seed main component, apiol, efficient approach to polymethoxyquinone C3- and C4-acids was developed. The key step of this approach is Baeyer–Villiger rearrangement of carbonyl-substituted polyalkoxybenzenes derived from parsley seed extracts. These acids are the MeO-analogues of natural antioxidants – metabolites of ubiquinone and idebenone. Due to antioxidant properties, they are the potential therapeutic candidates for the treatment of mitochondrial dysfunction.

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Synthesis of Methoxy Analogues of Coenzyme Q10 Metabolites from Parsley Seed Extracts via Baeyer–Villiger Rearrangement of Carbonyl-Substituted Polyalkoxybenzenes

Semenov,

Demchuk,

Adaeva

et al. 2024

Synthesis

Self Cite

View full text Add to dashboard Cite

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Synthesis of Polyalkoxymethylenedioxy-1,4-naphthoquinones from Parsley Seed Metabolite

Varakutin,

Muravsky,

Khrustalev

et al. 2024

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A convenient synthesis of polyalkoxy-1,4-naphthoquinones, good starting materials for analogues of natural quinones, has been developed. Bromonaphthoquinone, more stable than its hydroxylated analogue, turned out to be a convenient and accessible key synthon for the preparation of various polyalkoxylated naphthoquinones. The obtained quinones could be useful starting materials for the preparation of biologically active polymethoxy- and hydroxy-methylenedioxynaphthoquinones.

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Synthesis of tetraalkoxyaryldihydrobenzo[g]indazoles from metabolites of dill and parsley seeds essential oil

Cited by 2 publications

References 20 publications

Synthesis of Methoxy Analogues of Coenzyme Q10 Metabolites from Parsley Seed Extracts via Baeyer–Villiger Rearrangement of Carbonyl-Substituted Polyalkoxybenzenes

Synthesis of Methoxy Analogues of Coenzyme Q10 Metabolites from Parsley Seed Extracts via Baeyer–Villiger Rearrangement of Carbonyl-Substituted Polyalkoxybenzenes

Synthesis of Polyalkoxymethylenedioxy-1,4-naphthoquinones from Parsley Seed Metabolite

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