Synthesis of Tetracyclic 5‐Azaindole Analogues by Palladium‐Catalyzed Sequential Annulation.

Abstract

Tetracyclic 5-azaindole analogues were prepared by palladium-catalyzed sequential annulation of benzylidene(3-iodopyridinyl-4-yl)amine and 1-aryl substituted internal alkynes under Pd(OAc) 2 , n-Bu4NCl, and Et 3 N at 120 °C. The synthetic procedure showed possible diversification of tetracyclic 5-azaindole analogues by varying the 1-aryl substituent in internal alkynes.