Synthesis of Tetracyclic Benzazole–Condensed Quinazolinones through Triphenylbismuth Dichloride Assisted Cyclodesulfurization
Yuki Murata,
Shuji Yasuike,
Arisu Koyanagi
et al.
Abstract:Benzazole-condensed quinazolinones, such as benzo[4,5]imidazo[2,1-b]- and benzo[4,5]oxazolo[2,3-b]quinazolinones are of a great interest because of their potential applications as biologically active substances. Herein, we report that the treatment of various o-phenylenediamines with methyl 2-isothiocyanatobenzoate afforded thioxoquinazolinones, which were reacted in situ with triphenylbismuth dichloride in the presence of K2CO3 to give the desired benzimidazoquinazolinones in good to excellent yields under m… Show more
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