Synthesis of Tetrasubstituted Thieno[3,2‐b]pyridin‐5(4H)‐one Derivatives as a Heterocyclic Scaffold for Multisite‐specific Fluorous Fluorescent Tagging and Fluorous Solid‐Phase Extraction
Abstract:Tetrasubstituted thieno[3,2‐b]pyridin‐5(4H)‐one derivatives were selected as a highly functionalized heterocyclic scaffold for a multisite‐specific tagging process utilizing a previously devised fluorous fluorescent tag system. A suitable synthetic method was established for the 7‐alkoxy‐2,4,6‐trisubstituted‐thieno[3,2‐b]pyridin‐5(4H)‐one derivatives, and incorporating t‐butoxycarbonyl‐functionalized building blocks into the reaction sequence produced precursors that could be used in the tagging process. Fluor… Show more
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