Synthesis of (+)-Tetronolide

Boeckman, Robert K.; Shao, Pan‐Lin; Wrobleski, Stephen T.; Boehmler, Debra J.; Heintzelman, Geoffrey R.; Barbosa, Antonio. J.

doi:10.1055/s-2006-955646

Search citation statements

Order By: Relevance

Paper Sections

Select...

Results1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2010

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Two products were isolated: the keto lactone 39 and the methyl ketone 40 (64% and 15%, respectively) (Scheme 9). The latter arises from competitive addition of water to 37 and subsequent decarboxylation of the resulting β-ketoacid, a phenomenon that has been observed by others 21. The relative amount of 40 increased over time.…”

Section: Resultsmentioning

confidence: 60%

Total Synthesis of (−)-Callipeltoside A

et al. 2010

View full text Add to dashboard Cite

A total synthesis of (−)-callipeltoside A (1) has been achieved. The core macrocycle was made via a dual macrolactonization/pyran hemiketal formation reaction, which was developed to circumvent issues related to the reversible nature of acylketene formation from β-keto lactone substrates. Initial approaches to the core of the natural product that revolved around ring-closing metathesis (RCM) and relay ring-closing metathesis (RRCM) reactions are also described.

show abstract

Section: Resultsmentioning

confidence: 60%