Synthesis of the dendritic type β-cyclodextrin on primary face via click reaction applicable as drug nanocarrier

Toomari, Yousef; Namazi, Hassan; Akbar, Entezami Ali

doi:10.1016/j.carbpol.2015.05.087

Cited by 63 publications

(21 citation statements)

References 40 publications

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“…[26] Undissolved compounds were removed by filtration and the solvent was evaporated under vacuum. The resulting mixture was stirred at 60 8Co vernight.…”

Section: Methodsmentioning

confidence: 99%

Efficient Synthesis of Muramic and Glucuronic Acid Glycodendrimers as Dengue Virus Antagonists

García‐Oliva

Cabanillas

Perona

et al. 2020

Chemistry A European J

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Carbohydrates are involved in manyi mportant pathological processes, such as bacterial and viral infections, by meanso fc arbohydrate-protein interactions. Glycoconjugates with multiple carbohydrates are involved in multivalent interactions, thus increasing their binding strengths to proteins. In this work, we report the efficient synthesis of novel muramic and glucuronic acid glycodendrimers as potential Denguev irus antagonists. Aromatic scaffolds functionalized with at erminal ethynylg roups were coupledt o muramic and glucuronic acid azides by click chemistry througho ptimized synthetic strategiest oa fford the desired glycodendrimers with high yields. Surface Plasmon Resonance studies have demonstrated that the compounds reported bind efficiently to the Dengue virus envelopeprotein. Molecular modelling studies were carried out to simulate and explain the binding observed. These studies confirm that efficient chemical synthesis of glycodendrimers can be broughta bout easily offering av ersatile strategy to find new active compounds against Dengue virus.

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“…[26] Undissolved compounds were removed by filtration and the solvent was evaporated under vacuum. The resulting mixture was stirred at 60 8Co vernight.…”

Section: Methodsmentioning

confidence: 99%

Efficient Synthesis of Muramic and Glucuronic Acid Glycodendrimers as Dengue Virus Antagonists

García‐Oliva

Cabanillas

Perona

et al. 2020

Chemistry A European J

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“…The synthesize of b-CD-BCN was following previous reports (Jiang et al, 2014;Toomari et al, 2015). b-CD-OTs (264 mg, 205 mmol), BCN-amine (100 mg, 308 mmol) and Et3N (60 mg, 600 mmol) were dissolved in dry DMF and stirring under nitrogen flow.…”

Section: Star+methodsmentioning

confidence: 99%

Multistage signal-interactive nanoparticles improve tumor targeting through efficient nanoparticle-cell communications

Zhang

Kong

et al. 2021

Cell Reports

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“…It is worth noticing that this synthetic step was crucial in the design of our PDCs. In particular, the βCD tosylation method provided high yields compared to other previously reported methods [30,31]. Then, the tosyl group of compound E was replaced by an azide group through a nucleophilic substitution reaction to give compound F [32].…”

Section: Introductionmentioning

confidence: 93%

First Class of Phosphorus Dendritic Compounds Containing β-Cyclodextrin Units in the Periphery Prepared by CuAAC

et al. 2020

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A new class of phosphorus dendritic compounds (PDCs) having a cyclotriphosphazene (P3N3) core and decorated with six β-cyclodextrin (βCD) units, named P3N3-[O-C6H4-O-(CH2)n-βCD]6, where n = 3 or 4 was designed, and the synthesis was performed using copper (I) catalyzed alkyne-azide cycloaddition (CuAAC). To obtain the complete substitution of the P3N3, two linkers consisting of an aromatic ring and an aliphatic chain of two different lengths were assessed. We found that, with both linkers, the total modification of the periphery was achieved. The two new obtained dendritic compounds presented a considerably high water solubility (>1 g/mL). The compounds comprised in this new class of PDCs are potential drug carrier candidates, since the conjugation of the βCD units to the P3N3 core through the primary face will not only serve as surface cover but, also, provide them the faculty to encapsulate various drugs inside the βCDs cavities.

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Synthesis of the dendritic type β-cyclodextrin on primary face via click reaction applicable as drug nanocarrier

Cited by 63 publications

References 40 publications

Efficient Synthesis of Muramic and Glucuronic Acid Glycodendrimers as Dengue Virus Antagonists

Efficient Synthesis of Muramic and Glucuronic Acid Glycodendrimers as Dengue Virus Antagonists

Multistage signal-interactive nanoparticles improve tumor targeting through efficient nanoparticle-cell communications

First Class of Phosphorus Dendritic Compounds Containing β-Cyclodextrin Units in the Periphery Prepared by CuAAC

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