Synthesis of the Naphthalene‐Derived Inhibitors Against Cdc25A Dual‐Specificity Protein Phosphatase and Their Biological Activity.

Abstract

Quinones Q 0910Synthesis of the Naphthalene-Derived Inhibitors Against Cdc25A Dual-Specificity Protein Phosphatase and Their Biological Activity. -A variety of naphthalene and naphthoquinone derivatives are synthesized and evaluated for their in vitro Cdc25A phosphatase-inhibitory activity. SAR studies indicate that the naphthoquinone core with a methoxy substituent, instead of a methylamino group as in natural pyranonaphthoquinones, is an important factor to show high activity of phosphatase inhibition. -(SHIMBASHI, A.; TSUCHIYA, A.; IMOTO, M.; NISHIYAMA*, S.; Bioorg. Med. Chem. Lett. 15 (2005) 1, 61-65; Dep. Chem., Fac. Sci. Technol., Keio Univ., Kohoku, Yokohama 223, Japan; Eng.) -R. Langenstrassen 15-088