Synthesis of the new ring systems indeno[1,2-d]pyrimidinones, indeno[1,2-e]pyrrolo[1,2-a]pyrimidinones and indeno[1,2-e]pyrimido[1,2-a]izoindoles

Abstract

[1,2-a]izoindoles were prepared as new ring systems by ring enlargement of azetidinone 2 and ring closure of amino ester 3 and 1,3-diamine 5. These ring closures resulted in pure diastereomers, the stereochemistry of which was determined by NMR spectroscopy.