Synthesis of the New Triheterocyclic System C3N-C4N-C6N. 3-Aryl-2,5,5-trimethyl-9a-methylsulfanyl-9-phenoxy-4,5,6,8,9,9a-hexahydro-3H-azeto[1,2-a]pyrrolo[3,2-c]azepin-8-ones

Martínez, Rodolfo; Ávila-Zárraga, José Gustavo; López-López, Gema; Nava-Salgado, Víctor Oswaldo

doi:10.3987/com-99-8662

Search citation statements

Order By: Relevance

Paper Sections

Select...

Methods1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2000

2009

Publication Types

Select...

Article4

Book2

Relationship

Self Cite1

Independent5

Authors

Journals

Cited by 7 publications

(1 citation statement)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The spectral data where in agreement with the reported data. 5 Compounds 4a', 4b', 4c', 4f' and 4g' are yellow amorphous solid 5 and they were used without further purification. Spectral data for the unknown methylsulfanylazepines 4d" and 4e" are described below …”

Section: Methodsmentioning

confidence: 99%

Cytotoxic evaluation of substituted azetopyrroloazepinones

Martı́nez¹,

Ávila-Zárraga²,

Ramírez³

et al. 2003

Arkivoc

Self Cite

View full text Add to dashboard Cite

Azetopyrroloazepinones 1a-g were synthesized in six steps from 5,5-dimethyl-1,3-cyclohexanedione as starting material in good yields. These compounds were tested on five tumoral cell lines with the aim of elucidating the relationship between the substituents attached to the 3-phenyl ring and their cytotoxic activity. The results are inconclusive in regard to the relationship between the physicochemical properties of the substituents on the 3-phenyl group of azeto-pyrroloazepinones 1a-g and the inhibition of the growth in tumor cell lines. However, the results show a clear link between the presence of halogens on position 3-or 4-and the cytotoxicity of these compounds.

show abstract

Section: Methodsmentioning

confidence: 99%