Synthesis of the Phosphoramidite Units for Benzene‐Glycol Nucleic Acid

Abstract

Benzene-glycol nucleic acid-DNA chimeras form thermally and thermodynamically stable duplexes with complementary RNAs, and have base-discriminating abilities. This unit describes the synthesis of four nucleoside analogs, an adenine, cytosine, thymine, and guanine analogs with base-benzene-glycol structure. The synthesis starts with conversion of (S)-mandelic acid in arylboronic acid derivative, common intermediate. Nucleobase coupling of the intermediate and phosphitylation afford to phosphoroamidite units. © 2017 by John Wiley & Sons, Inc.

Enantiospecific Analysis of Carboxylic Acids Using Cinchona Alkaloid Dimers as Chiral Solvating Agents

“…Meanwhile, cyclandelate and homatropine are used as anticoagulation and anticholinergic medications, respectively (Figure , III and IV). − Besides, mandelate derivatives can be readily transformed into other functionalized molecules, such as 1,2-diols, β-amino alcohols, and α-amino acid derivatives. Therefore, the use of pure enantiomeric mandelic acid and its derivatives in the study of their biofunctions and pharmacokinetics is critical in the organic and pharmaceutical industries. , …”

“…Therefore, the use of pure enantiomeric mandelic acid and its derivatives in the study of their biofunctions and pharmacokinetics is critical in the organic and pharmaceutical industries. 10,11 Currently, the detection of chiral enantiomers at the molecular level is mainly based on spectroscopy and chromatographic separation techniques. Among them, highperformance liquid chromatography, gas chromatography, capillary chromatography, supercritical fluid chromatography, and capillary electrophoresis on chiral stationary phase columns are the methods of choice.…”