Synthesis of thermosensitive magnetic nanocarrier for controlled sorafenib delivery

Heidarinasab, Amir; Panahi, Homayon Ahmad; Faramarzi, Mehdi; Farjadian, Fatemeh

doi:10.1016/j.msec.2016.05.036

Cited by 45 publications

(21 citation statements)

References 37 publications

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“…For SOR the typical adsorption-desorption studies are rarely met in literature (Heidarinasa et al 2016;Zheng et al 2018) thus the mechanism of releasing is not fully understood. In order to shed some light to observed phenomena, i.e.…”

Section: Resultsmentioning

confidence: 99%

New strategy of controlled, stepwise release from novel MBioF and its potential application for drug delivery systems

et al. 2019

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Metal organic structures have gained recently an interest in many fields. Among them, metal-biomolecule framework materials with amino acids applied as organic linkers have attracted the growing attention. An application of tailored metal-biomolecule frameworks, easily decomposing in an acidic and/or reductive environment in a steerable way, is reported here. From these biocompatible, non-porous, and nanostructured drug carrier systems, the desirable portion of drug could be released depending on the portion of acid, i.e. immediately and/or in a multi-step process due to a structure decomposition. The application of naturally occurring elements as cystine ensures full biocompatibility of the obtained system as well as its degradation products. Presented materials offer potential application in drug delivery systems.

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Section: Resultsmentioning

confidence: 99%

New strategy of controlled, stepwise release from novel MBioF and its potential application for drug delivery systems

et al. 2019

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“…The modified Fe 3 O 4 MNPs (3 g), NIPAM (2 g), AGE (10 mL) and 2,2′‐azobis(2‐methylpropionitrile) (0.1 g) were mixed in ethanol (30 mL) and refluxed at 65°C for 7 h under N 2 atmosphere . The polymer grafted MNPs (MNPs‐AGE/NIPAM) were separated magnetically and washed with deionized water and then ethanol.…”

Section: Methodsmentioning

confidence: 99%

Magnetic iron oxide nanoparticles graftedN-isopropylacrylamide/chitosan copolymer for the extraction and determination of letrozole in human biological samples

Moazen

Panahi

2017

J. Sep. Sci.

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Magnetic iron oxide nanoparticles are used for the extraction of a drug from an aqueous solution. In the current study, the magnetic iron oxide nanoparticles were synthesized via a facile coprecipitation approach, and then modified by (3-mercaptopropyl)trimethoxysilane followed by grafting thermosensitive polymer N-isopropylacrylamide and biopolymer chitosan. Structure, morphology, size, thermal resistance, specific surface area, and magnetic properties of the grafted nanosorbent were characterized by using Fourier transform infrared spectroscopy, field emission scanning electron microscopy, transmission electron microscopy, elemental analysis, thermogravimetric analysis, specific surface area analysis and vibrating sample magnetometry. The effective parameters on sorption/desorption of letrozole on grafted magnetic nanosorbent were evaluated. The best sorption of letrozole via the grafted nanosorbent occurred at 20°C at an optimum pH of 7. The extraction of trace letrozole in human biological fluids is investigated and revealed 89.1 and 97.8% recovery in plasma and urine, respectively.

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“…Hence, it reduces tumour growth leading to significantly improved survival rates [1,2]. However, a pronounced lipophilicity of the molecule is responsible for the poor bioavailability and distribution of the compound into healthy tissues [2,3]. As a consequence, drug therapy is accompanied by serious side effects and a high dose is required.…”

Section: Introductionmentioning

confidence: 99%

“…Against this background, nanocarrier-based delivery of sorafenib has the potential to improve drug therapy significantly. Theranostic nanodelivery systems offer a versatile combination of therapeutic and diagnostic features and have been applied to this task earlier [3,4]. A variety of contrast agents such as gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA), shorten the longitudinal relaxation time, and were widely used for both vascular and tumor magnetic resonance imaging (MRI) [4,5].…”

Section: Introductionmentioning

confidence: 99%

“…In this context, Gd-DTPA-conjugated human serum albumin (HSA) nanoparticles improved the contrast of MRI compared to Gd-DTPA aqueous solution in vivo [3][4][5]. Unfortunately, even after conjugation of polyethylene glycol (PEG) to the particle surface, HSA nanoparticles exhibit only short circulation time [6] and the potential for scale-up of this technology is rather limited [7].…”

Section: Introductionmentioning

confidence: 99%

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Theranostic polymeric nanocarriers modified by enhanced gadolinium conjugation techniques

Feczkó¹,

Piiper²,

Pleli³

et al. 2019

Preprint

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Background: Efficient delivery of the poorly water-soluble compound sorafenib still poses a challenge to current formulation strategies. To incorporate the lipophilic molecule into biocompatible and biodegradable theranostic nanoparticles has great potential for improving efficacy and safety of cancer therapy. Results: In this study, sorafenib nanoencapsulation was optimized using poly(D,L-lactide-co-glycolide) and polyethylene glycol-poly(D,L-lactide-co-glycolide) copolymers comparing three different technologies. The particles ranged in size between 220 and 240 nm with encapsulation efficiencies from 76.1 ± 1.7 % to 69.1 ± 10.1 %. A remarkable maximum drug load of 9.0 % was achieved. Finally, a gadolinium complex was covalently attached to the nanoparticle surface transforming the nanospheres into theranostic devices allowing the localization using magnetic resonance imaging. Conclusion: The manufacture of sorafenib-loaded nanoparticles and the functionalization of the particle surface with a gadolinium complex resulted in a high drug loading, a strong MRI signal, optimal stability features and a sustained release profile.

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Synthesis of thermosensitive magnetic nanocarrier for controlled sorafenib delivery

Cited by 45 publications

References 37 publications

New strategy of controlled, stepwise release from novel MBioF and its potential application for drug delivery systems

New strategy of controlled, stepwise release from novel MBioF and its potential application for drug delivery systems

Magnetic iron oxide nanoparticles graftedN-isopropylacrylamide/chitosan copolymer for the extraction and determination of letrozole in human biological samples

Theranostic polymeric nanocarriers modified by enhanced gadolinium conjugation techniques

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