Synthesis of thiol-derivatised gold nanoparticles in a two-phase Liquid–Liquid system

Brust, Mathias; Walker, Merryl; Bethell, Donald; Schiffrin, David J.; Whyman, Robin

doi:10.1039/c39940000801

Cited by 6,811 publications

(6,470 citation statements)

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“…The presence of a peak around 164 eV is indicative of a covalently bound sulfur atom at the surface. This binding energy is slightly higher than the thiolate (R-S Ϫ ) value normally found in alkane thilolate monolayers (162-164 eV) (12). The shift in the peak position to a higher value upon complexation is indicative of electron transfer to C 60 in accordance with the expectation.…”

Section: Resultssupporting

confidence: 85%

Charge-Transfer Complexation of C60 with Diphenyltetrathiafulvalene (DPTTF) Capped Gold Clusters

Resmi

Sandhyarani

Unnikrishnan

et al. 1999

Journal of Colloid and Interface Science

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4,4 -Diphenyltetrathiafulvalene (DPTTF) capped gold nanoparticles of 3-to 5-nm diameter have been prepared and their thermal stability has been investigated by variable temperature FT-IR spectroscopy. The DPTTF molecules at the cluster surface undergo charge-transfer complexation with C 60 to form Au/ DPTTF.C 60 . Direct evidence of complexation is observed in the x-ray photoelectron and infrared spectra of the clusters. The orientational ordering transition of C 60 in Au/DPTTF.C 60 clusters occur at a higher temperature than pure C 60 indicating increased resistance to orientational disorder due to charge transfer. Variable-temperature infrared spectroscopic studies yield complementary information. Both FT-IR and mass spectra show that some of the sites on the gold surface are occupied by the phase-transfer reagent used in the cluster preparation.

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Section: Resultssupporting

confidence: 85%

Charge-Transfer Complexation of C60 with Diphenyltetrathiafulvalene (DPTTF) Capped Gold Clusters

Resmi

Sandhyarani

Unnikrishnan

et al. 1999

Journal of Colloid and Interface Science

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“…The synthesis of thiol-derivatized stable gold nanoparticles was first reported by Brust and Schiffrin in the mid of 1990. 11 Following this seminal work, various methods have been developed so far to synthesize monodisperse gold nanocluster of definite particle sizes by controlling the initial reaction conditions such as the thiol-to-gold ion ratio, reducing agents, temperature and also by modifying the post-synthesis purification processes. Several well defined nanoclusters have been synthesized so far such as Au 20 (SR) 16 , Au 25 (SR) 18 , Au 38 (SR) 24 , Au 102 (SR) 44 , and Au 144 (SR) 60 .…”

Section: Introductionmentioning

confidence: 99%

A facile one-pot synthesis of blue and red luminescent thiol stabilized gold nanoclusters: a thorough optical and microscopy study

Pal

Kryschi

2015

Phys. Chem. Chem. Phys.

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Here in this contribution, blue and red luminescent 1-dodecanethiol (DT) terminated gold nanoclusters (AuNC) were prepared by a simple two-step synthesis route where the first step involved the surfactantfree synthesis of bare AuNC in N,N 0 -dimethylformamide (DMF) and the second step is the termination of the as-prepared bare AuNC by 1-dodecanethiol. The blue and red luminescent DT-terminated AuNC were isolated by a solvent-induced precipitation followed by an ultra-centrifugation technique. Both the bare AuNC and the blue and red luminescent DT-terminated AuNC exhibit stable photoluminescence and good solubility in various solvents. The photo-physical, electronic, structural, and morphological properties of the bare AuNC and the blue and red luminescent DT-terminated AuNC were examined by performing UV-Vis absorption spectroscopy, stationary and time-resolved PL spectroscopy, X-ray photoelectron spectroscopy (XPS), femtosecond transient absorption spectroscopy, Fourier-transform infrared spectroscopy (FTIR-ATR), and high-resolution transmission electron microscopy (HRTEM) experiments.

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“…We then functionalized the surface of the AuNPs with a carboxylic acid-terminated poly(ethylene glycol) (PEG) linker ( Figure 1) through exchange of 1-propanethiol-protected AuNPs 25 with PEG-functionalized thiol ligands in dichloromethane (see the SI). The PEG-functionalized AuNPs (PEG-AuNPs) were negatively charged (ζ potential = À39.6 mV) in PBS (pH 7.4) with an average particle diameter of 3 nm, as determined by transmission electron microscopy (TEM) ( Figure S3b in the SI).…”

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confidence: 99%

Luciferase and Luciferin Co-immobilized Mesoporous Silica Nanoparticle Materials for Intracellular Biocatalysis

et al. 2011

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We report a gold nanoparticle (AuNP)-capped mesoporous silica nanoparticle (Au-MSN) platform for intracellular codelivery of an enzyme and a substrate with retention of bioactivity. As a proof-of-concept demonstration, Au-MSNs are shown to release luciferin from the interior pores of MSN upon AuNP uncapping in response to disulfide-reducing antioxidants and codeliver bioactive luciferase from the PEGylated exterior surface of Au-MSN to Hela cells. The effectiveness of luciferase-catalyzed luciferin oxidation and luminescence emission in the presence of intracellular ATP was measured by a luminometer. Overall, the chemical tailorability of the Au-MSN platform to retain enzyme bioactivity, the ability to codeliver enzyme and substrate, and the potential for imaging tumor growth and metastasis afforded by intracellular ATP-and glutathione-dependent bioluminescence make this platform appealing for intracellular controlled catalysis and tumor imaging. ABSTRACT: We report a gold nanoparticle (AuNP)-capped mesoporous silica nanoparticle (Au-MSN) platform for intracellular codelivery of an enzyme and a substrate with retention of bioactivity. As a proof-of-concept demonstration, Au-MSNs are shown to release luciferin from the interior pores of MSN upon AuNP uncapping in response to disulfide-reducing antioxidants and codeliver bioactive luciferase from the PEGylated exterior surface of Au-MSN to Hela cells. The effectiveness of luciferase-catalyzed luciferin oxidation and luminescence emission in the presence of intracellular ATP was measured by a luminometer. Overall, the chemical tailorability of the Au-MSN platform to retain enzyme bioactivity, the ability to codeliver enzyme and substrate, and the potential for imaging tumor growth and metastasis afforded by intracellular ATP-and glutathionedependent bioluminescence make this platform appealing for intracellular controlled catalysis and tumor imaging.

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Synthesis of thiol-derivatised gold nanoparticles in a two-phase Liquid–Liquid system

Abstract: Using two-phase (water-toluene) reduction of AuC14-by sodium borohydride in the presence of an alkanethiol, solutions of 1-3 nm gold particles bearing a surface coating of thiol have been prepared and characterised; this novel material can be handled as a simple chemical compound.

Cited by 6,811 publications

References 11 publications

Charge-Transfer Complexation of C60 with Diphenyltetrathiafulvalene (DPTTF) Capped Gold Clusters

Charge-Transfer Complexation of C60 with Diphenyltetrathiafulvalene (DPTTF) Capped Gold Clusters

A facile one-pot synthesis of blue and red luminescent thiol stabilized gold nanoclusters: a thorough optical and microscopy study

Luciferase and Luciferin Co-immobilized Mesoporous Silica Nanoparticle Materials for Intracellular Biocatalysis

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