Mixed-position kinematic synthesis is used to not only reach a certain number of precision positions, but also impose certain instantaneous motion conditions at those positions. In the traditional approach, one end-effector twist is defined at each precision position in order to achieve better guidance of the end-effector along a desired trajectory. For one-degree-of-freedom linkages, that suffices to fully specify the trajectory locally. However, for systems with a higher number of degrees of freedom, such as robotic systems, it is possible to specify a complete higher-dimensional subspace of potential twists at particular positions. In this work, we focus on the 3R serial chain. We study the three-dimensional subspaces of twists that can be defined and set the mixed-position equations to synthesize the chain. The number and type of twist systems that a chain can generate depend on the topology of the chain; we find that the spatial 3R chain can generate seven different fully defined twist systems. Finally, examples of synthesis with several fully defined and partially defined twist spaces are presented. We show that it is possible to synthesize 3R chains for feasible subspaces of different types. This allows a complete definition of potential motions at particular positions, which could be used for the design of precise interaction with contact surfaces.