Synthesis of triazole-linked pseudo-oligosialic acid derivatives

Formation of 1,2‐trans‐arabinofuranoside linkage in arabinans from Mycobacterium tuberculosis using differently protected Ara‐β‐(1→2)‐Ara disaccharide glycosyl donors in the absence of a participating group at O‐2 was studied. The influence of the nature of the protective and leaving groups in glycosyl donors on the efficiency and stereoselectivity of the 1,2‐trans‐arabinofuranosylation was investigated. The efficiency of Ara‐β‐(1→2)‐Ara p‐tolyl thioglycoside containing five triisopropylsilyl groups in 1,2‐trans‐stereoselective synthesis of a protected tetrasaccharide corresponding to a fragment of the M. tuberculosis arabinan was shown for the first time. On the contrary, the use of glycosyl donors based on Ara‐β‐(1→2)‐Ara containing only benzoyl or both silyl and benzoyl groups led to the loss of stereocontrol.

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Five Triisopropylsilyl Substituents in Ara‐β‐(1→2)‐Ara Disaccharide Glycosyl Donor Make Unselective Glycosylation Reaction Stereoselective

Abronina

Malysheva

Степанова

et al. 2022

Eur J Org Chem

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Synthesis of selectively protected α-(1→3)- and α-(1→5)-linked octasaccharide moiety bearing a Janus aglycone, related to the branching site of mycobacterial polysaccharides

Abronina

Shvyrkina²,

Zinin³

et al. 2022

Russ Chem Bull

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Synthesis of a tetrasaccharide containing Janus aglycone related to the terminal fragment of polysaccharides of mycobacteria

et al. 2023

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Synthesis of triazole-linked pseudo-oligosialic acid derivatives

Cited by 4 publications

References 53 publications

Five Triisopropylsilyl Substituents in Ara‐β‐(1→2)‐Ara Disaccharide Glycosyl Donor Make Unselective Glycosylation Reaction Stereoselective

Five Triisopropylsilyl Substituents in Ara‐β‐(1→2)‐Ara Disaccharide Glycosyl Donor Make Unselective Glycosylation Reaction Stereoselective

Synthesis of selectively protected α-(1→3)- and α-(1→5)-linked octasaccharide moiety bearing a Janus aglycone, related to the branching site of mycobacterial polysaccharides

Synthesis of a tetrasaccharide containing Janus aglycone related to the terminal fragment of polysaccharides of mycobacteria

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