Synthesis of Two Types of Nanoparticles in Polyelectrolyte Capsule Nanoreactors and Their Dual Functionality

Choi, Won San; Koo, Hye Young; Park, Jeong-Ho; Kim, Dong‐Yu

doi:10.1021/ja053981u

Cited by 53 publications

(35 citation statements)

References 30 publications

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“…Integration of nanoparticles with polymer capsules is desirable for multifunctional applications (release of cargo, enhance mechanical properties, etc) [14], [15], and can be achieved by incorporating nanoparticles within the two available compartments in PEM capsules, namely- shell and the cavity. To this end of loading nanoparticles in the shell of polymer capsules, few reports are available on the development of multifunctional PEM capsules which possess optical/magnetic nanoparticles sandwiched between the PEM layers along with the prospect of filling the cavity with desirable cargo [16]–[19]. Koo et al have reported loading of gold nanorods on the surface of polymer capsules [20].…”

Section: Introductionmentioning

confidence: 99%

Generic Delivery of Payload of Nanoparticles Intracellularly via Hybrid Polymer Capsules for Bioimaging Applications

et al. 2012

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Towards the goal of development of a generic nanomaterial delivery system and delivery of the ‘as prepared’ nanoparticles without ‘further surface modification’ in a generic way, we have fabricated a hybrid polymer capsule as a delivery vehicle in which nanoparticles are loaded within their cavity. To this end, a generic approach to prepare nanomaterials-loaded polyelectrolyte multilayered (PEM) capsules has been reported, where polystyrene sulfonate (PSS)/polyallylamine hydrochloride (PAH) polymer capsules were employed as nano/microreactors to synthesize variety of nanomaterials (metal nanoparticles; lanthanide doped inorganic nanoparticles; gadolinium based nanoparticles, cadmium based nanoparticles; different shapes of nanoparticles; co-loading of two types of nanoparticles) in their hollow cavity. These nanoparticles-loaded capsules were employed to demonstrate generic delivery of payload of nanoparticles intracellularly (HeLa cells), without the need of individual nanoparticle surface modification. Validation of intracellular internalization of nanoparticles-loaded capsules by HeLa cells was ascertained by confocal laser scanning microscopy. The green emission from Tb3+ was observed after internalization of LaF3:Tb3+(5%) nanoparticles-loaded capsules by HeLa cells, which suggests that nanoparticles in hybrid capsules retain their functionality within the cells. In vitro cytotoxicity studies of these nanoparticles-loaded capsules showed less/no cytotoxicity in comparison to blank capsules or untreated cells, thus offering a way of evading direct contact of nanoparticles with cells because of the presence of biocompatible polymeric shell of capsules. The proposed hybrid delivery system can be potentially developed to avoid a series of biological barriers and deliver multiple cargoes (both simultaneous and individual delivery) without the need of individual cargo design/modification.

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Section: Introductionmentioning

confidence: 99%

Generic Delivery of Payload of Nanoparticles Intracellularly via Hybrid Polymer Capsules for Bioimaging Applications

et al. 2012

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“…To date, there are only few examples of antibacterial delivery system based on polyelectrolyte microcapsules. These examples employed the biocide‐leaching strategy either by inserting an antibacterial drug, ciproflaxine, into the core or shell of the capsule33, 34 or by inserting nanoparticles into the shell of the capsules 35…”

Section: Introductionmentioning

confidence: 99%

Contact‐Killing Polyelectrolyte Microcapsules Based on Chitosan Derivatives

Cui

Szarpak

Pignot-Paintrand

et al. 2010

Adv Funct Materials

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Polyelectrolyte‐multilayer microcapsules are made by layer‐by‐layer (LbL) assembly of oppositely charged polyelectrolytes onto sacrificial colloidal particles, followed by core removal. In this paper, contact‐killing polyelectrolyte microcapsules are prepared based solely on polysaccharides. To this end, water‐soluble quaternized chitosan (QCHI) with varying degrees of substitution (DS) and hyaluronic acid (HA) are assembled into thin films. The quaternary ammonium groups are selectively grafted on the primary amine group of chitosan by exploiting its reaction with glycidyltrimethylammonium chloride (GTMAC) under homogeneous aqueous acidic conditions. The morphology of the capsules is closely dependent on the DS of the quaternized chitosan derivatives, which suggests differences in their complexation with HA. The DS is also a key parameter to control the antibacterial activity of QCHI against Escherichia Coli (E. coli). Thus, capsules containing the QCHI derivative with the highest DS are shown to be the most efficient to kill E. coli while retaining their biocompatibility toward myoblast cells, which suggests their potential as drug carriers able to combat bacterial infections.

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“…Many of the systems currently in progress, particularly those for molecule entrapment and delivery, draw their inspiration by an elegant, environmentally benign and simple process based on the layer-by-layer (LbL) self-assembly technology [3,4]. Different multilayered carriers composed of polyelectrolytes or other macromolecules have been developed on nano-scale for successful incorporation of functional substances such as dyes [5], proteins [6], enzymes [7,8], cells [9] and inorganic crystals [10,11]. And relevant studies focused essentially on physical, chemical and biological properties with respect to these novel structures [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Hepatic-targeting microcapsules construction by self-assembly of bioactive galactose-branched polyelectrolyte for controlled drug release system

Zhang

Chen

et al. 2008

Journal of Colloid and Interface Science

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Synthesis of Two Types of Nanoparticles in Polyelectrolyte Capsule Nanoreactors and Their Dual Functionality

Cited by 53 publications

References 30 publications

Generic Delivery of Payload of Nanoparticles Intracellularly via Hybrid Polymer Capsules for Bioimaging Applications

Generic Delivery of Payload of Nanoparticles Intracellularly via Hybrid Polymer Capsules for Bioimaging Applications

Contact‐Killing Polyelectrolyte Microcapsules Based on Chitosan Derivatives

Hepatic-targeting microcapsules construction by self-assembly of bioactive galactose-branched polyelectrolyte for controlled drug release system

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