Synthesis of W-Phenylalkyldimethylamines from Corresponding Alcohols

Catalytic amination of aliphatic alcohols. Role of hydrogen as inhibitor for catalyst deactivation

“…The amination conducted with a,a-dideuterated 1-octanol showed a marked kinetic isotope effect and yielded no dideuterated amines in the product mixture. This point is substantiated by successful experiments performed without hydrogen in an autoclave (Baiker and Richarz, 1977a). Reaction 1 indicates that from a stoichiometric point of view, no additional hydrogen should be necessary if the reaction is carried out in a batch system.…”

“…This result is in accordance with that reported earlier by Kliger et al (1975) for the amination of a,adideuterated 1-octanol with ammonia on a molten iron catalyst. In addition to the amination reaction discussed, the reactant amine can undergo disproportionation on amination catalysts under normal amination process conditions (Baiker and Richarz, 1977a). This point is substantiated by successful experiments performed without hydrogen in an autoclave (Baiker and Richarz, 1977a).…”

“…Catalyst preparation, pretreatment, and reduction were the same as described previously (Baiker and Richarz, 1978). Catalyst preparation, pretreatment, and reduction were the same as described previously (Baiker and Richarz, 1978).…”

“…cobalt catalysts proved to be very selective for this reaction, whereas nickel shows only moderate selectivity (Baiker and Richarz, 1977a).…”

Amination Reactions

“…Depending on the reactants (alcohol and amine), various amines can be produced by catalytic amination. Alcohols used so far include simple aliphatic alcohols [2][3][4]18], alcohols which contain a substituent in the aliphatic chain such as alkoxy-alcohols [19], phenoxyalkyl alcohols [20], and phenyl-alkyl alcohols [21].…”