Synthesis of Water-Dispersible Fluorescent, Radio-Opaque, and Paramagnetic CdS:Mn/ZnS Quantum Dots:  A Multifunctional Probe for Bioimaging

Abstract

Ultra-small (3.1 nm) multifunctional CdS:Mn/ZnS core-shell semiconductor quantum dots (Qdots), which possess fluorescent, radio-opacity, and paramagnetic properties, have been shown here. To demonstrate in vivo bioimaging capability, a rat was administered endovascularly with Qdots conjugated with a TAT peptide. The labeling efficacy of these Qdots was demonstrated on the basis of the histological analysis of the microtome sliced brain tissue, clearly showing that TAT-conjugated Qdots stained brain blood vessels.

Self-organization of an optomagnetic CoFe2O4–ZnS nanocomposite: preparation and characterization

“…Zinc sulfide (group II-VI semiconductor, direct wide band gap) nanoparticles have recently attracted significant attention because of their applications in biology and optoelectronic devices [28][29][30][31][32]. In general, the synthesis temperature has a significant effect on the crystal growth, structure and optical properties of the QDs.…”

In vitro and in vivo studies on gelatin-siloxane nanoparticles conjugated with SynB peptide to increase drug delivery to the brain

“…With further attachment of the positively charged SynB peptide, the zeta potential value increased to 31.82 ± 3.11 mV, which makes it possible to deliver plasmid DNA to the brain without compromising the blood-brain barrier. 25 These cationic nanoparticles are thus likely to bind to the anionic luminal plasma membrane, and subsequently become internalized into cells via endocytosis. 26 The ability of these nanoparticles to cross the blood-brain barrier was investigated using an in vitro cocultured model consisting of primary rat brain capillary endothelial cells and astrocytes.…”

Functional Inorganic Nanohybrids for Biomedical Diagnosis

“…The fluorescent visualisation of the whole rat brain was achieved using a simple low power handheld UV lamp, indicating that these materials are potentially applicable for advanced multimodal detection. [78] One of the main problems in the preparation of the fluorescent-magnetic nanohybrids is the risk of quenching of the fluorophore on the surface of the particle by the magnetic core. This quenching process could be occurred because of the fluorophore contact with the particle surface, resulting in an energy transfer process.…”