Synthesis of water-soluble and bio-taggable CdSe@ZnS quantum dots

Ramalingam, G.; Saravanan, K.; Vizhi, T. Kayal; Rajkumar, M.; Baskar, Kathirvelu

doi:10.1039/c7ra13400b

Cited by 31 publications

(15 citation statements)

References 56 publications

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“…As seen in Figure , absorption intensity increased at different concentrations, as the intensity of the fluorescence spectrum increased. The absorption and emission edges are a clear indication of a visible light response from the particles, indicating that CQDs could be used for various fluorescence and biological applications …”

Section: Resultsmentioning

confidence: 99%

Facile preparation of high fluorescent carbon quantum dots from orange waste peels for nonlinear optical applications

et al. 2019

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A facile and eco‐friendly hydrothermal method was used to prepare carbon quantum dots (CQDs) using orange waste peels. The synthesized CQDs were well dispersed and the average diameter was 2.9 ± 0.5 nm. Functional group identification of the CQDs was confirmed by Fourier transform infrared spectrum analysis. Fluorescence properties of the synthesized CQDs exhibited blue emission. The fluorescence quantum yield of the CQDs was around 11.37% at an excitation wavelength of 330 nm. The higher order nonlinear optical properties were examined using a Z‐scan technique and a continuous wave laser that was operated at a wavelength of 532 nm. Results demonstrated that the synthesis of CQDs can be considered as promising for optical switching devices, bio‐scanning, and bio‐imaging for optoelectronic applications.

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Section: Resultsmentioning

confidence: 99%

Facile preparation of high fluorescent carbon quantum dots from orange waste peels for nonlinear optical applications

et al. 2019

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“…The method of synthesizing QDs can play an important role in the overall toxicity, with literature reports indicating that QDs synthesized in organic solvents tend to be more toxic than those synthesized by aqueous pathways [53,54,55,56]. However, the toxicity of Cd-based QDs has largely been attributed to the free Cd ions existing in equilibrium with the QDs in solution [13,36,57].…”

Section: Resultsmentioning

confidence: 99%

Nanoparticles for Bioapplications: Study of the Cytotoxicity of Water Dispersible CdSe(S) and CdSe(S)/ZnO Quantum Dots

et al. 2019

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Semiconductor nanocrystals or quantum dots (QDs) have unique optical and physical properties that make them potential imaging tools in biological and medical applications. However, concerns over the aqueous dispersivity, toxicity to cells, and stability in biological environments may limit the use of QDs in such applications. Here, we report an investigation into the cytotoxicity of aqueously dispersed CdSe(S) and CdSe(S)/ZnO core/shell QDs in the presence of human colorectal carcinoma cells (HCT-116) and a human skin fibroblast cell line (WS1). The cytotoxicity of the precursor solutions used in the synthesis of the CdSe(S) QDs was also determined in the presence of HCT-116 cells. CdSe(S) QDs were found to have a low toxicity at concentrations up to 100 µg/mL, with a decreased cell viability at higher concentrations, indicating a highly dose-dependent response. Meanwhile, CdSe(S)/ZnO core/shell QDs exhibited lower toxicity than uncoated QDs at higher concentrations. Confocal microscopy images of HCT-116 cells after incubation with CdSe(S) and CdSe(S)/ZnO QDs showed that the cells were stable in aqueous concentrations of 100 µg of QDs per mL, with no sign of cell necrosis, confirming the cytotoxicity data.

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“…Moreover, QDs are beneficial in immunochemistry via molecular tracking. They represent better alternatives for the fluorescent beads that are mainly employed for studying the dynamics of neurotransmitter receptors because of their very small size (approximately 1–10 nm) compared to latex beads (approximately 500 nm) [ 107 ]. The QDs also function as biological luminescent markers capable of recognizing molecular structures.…”

Section: Biomedical Applications Of Qdsmentioning

confidence: 99%

Superior Properties and Biomedical Applications of Microorganism-Derived Fluorescent Quantum Dots

et al. 2020

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Quantum dots (QDs) are fluorescent nanocrystals with superb photo-physical properties. Applications of QDs have been exponentially increased during the past decade. They can be employed in several disciplines, including biological, optical, biomedical, engineering, and energy applications. This review highlights the structural composition and distinctive features of QDs, such as resistance to photo-bleaching, wide range of excitations, and size-dependent light emission features. Physical and chemical preparation of QDs have prominent downsides, including high costs, regeneration of hazardous byproducts, and use of external noxious chemicals for capping and stabilization purposes. To eliminate the demerits of these methods, an emphasis on the latest progress of microbial synthesis of QDs by bacteria, yeast, and fungi is introduced. Some of the biomedical applications of QDs are overviewed as well, such as tumor and microRNA detection, drug delivery, photodynamic therapy, and microbial labeling. Challenges facing the microbial fabrication of QDs are discussed with the future prospects to fully maximize the yield of QDs by elucidating the key enzymes intermediating the nucleation and growth of QDs. Exploration of the distribution and mode of action of QDs is required to promote their biomedical applications.

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Synthesis of water-soluble and bio-taggable CdSe@ZnS quantum dots

Abstract: Mystristic capped CdSe QDs with schematic diagram and formation mechanism of bio-taggable CdSe@ZnS QDs.

Cited by 31 publications

References 56 publications

Facile preparation of high fluorescent carbon quantum dots from orange waste peels for nonlinear optical applications

Facile preparation of high fluorescent carbon quantum dots from orange waste peels for nonlinear optical applications

Nanoparticles for Bioapplications: Study of the Cytotoxicity of Water Dispersible CdSe(S) and CdSe(S)/ZnO Quantum Dots

Superior Properties and Biomedical Applications of Microorganism-Derived Fluorescent Quantum Dots

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