Synthesis of well-defined amphiphilic poly(d,l-lactide)-b-poly(N-vinylpyrrolidone) block copolymers using ROP and xanthate-mediated RAFT polymerization

Ramesh, Kalyan; Mishra, Avnish Kumar; Patel, Vijay Kumar; Vishwakarma, Niraj Kumar; Biswas, Chandra Sekhar; Paira, Tapas K.; Mandal, Tarun K.; Maiti, Pralay; Misra, Nira; Ray, Biswajit

doi:10.1016/j.polymer.2012.10.009

Cited by 39 publications

(32 citation statements)

References 46 publications

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“…PSt-b-P4VBA shows the same characteristic peaks but with low intensity corroborating the presence of amorphous PSt macroRAFT in the copolymer. Ramesh et al has observed for PDLLA-b-PNVP, achieved similar results, denoting blocks miscibility, which is in agreement with the single glass transition temperature observed by them [27]. Figure 7 shows the SEM and STEM images of the PSt macroRAFT and PSt-b-P4VBA copolymer.…”

Section: Resultssupporting

confidence: 83%

Synthesis and characterization of polystyrene-block-poly(vinylbenzoic acid): a promising compound for manipulating photoresponsive properties at the nanoscale

et al. 2015

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Using reversible addition-fragmentation chain transfer (RAFT) polymerization, the effect of PSt macro-RAFT and 4VBA ratio on the synthesis of a carboxylic acid functional block copolymer (PSt-b-P4VBA) was studied. PSt macroRAFT polymer was initially prepared followed by the insertion of 4-vinylbenzoic acid (4VBA) monomer. The chemical structure of the diblock copolymer was confirmed by NMR and FTIR. The effect of PSt macroRAFT and 4VBA ratio on copolymerization yield and on molecular weight distribution was assessed by gel permeation chromatography. The rate of polymerization did not change as the 4VBA/PSt macroRAFT ratio increased, indicating an ideal amount of 4VBA insertion. An optimal ratio of [PSt macroRAFT]:[AIBN]:[4VBA] was 1.2:1:180. DSC and XRD confirmed the amorphous structure of homo and copolymer. Thermal stability was higher for PSt-b-P4VBA forming activated porous carbon char by dehydration, carbonization and oxidation. SEM and STEM observations showed a morphological evolution between PSt macroRAFT and the correspondent copolymer.

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Section: Resultssupporting

confidence: 83%

Synthesis and characterization of polystyrene-block-poly(vinylbenzoic acid): a promising compound for manipulating photoresponsive properties at the nanoscale

et al. 2015

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“…S8, Supporting information). The observed critical micellar concentration (CMC)s of block copolymers in water are 0.01 mg/mL and 0.012 mg/mL for runs 1 and 2, (Figure S9, Supporting information), respectively, as obtained by fluorescence spectroscopy using pyrene as probe ,. Interestingly, TEM study has revealed the formation of tiny 3.8 nm (diameter) micellar nanoparticles [Figure (a)].…”

Section: Resultsmentioning

confidence: 97%

“…due to their versatile and economic approaches . So, at this interface of chemistry, material and biomedical sciences, stimuli responsive amphiphilic block copolymers have hold a great deal of interest among researchers …”

Section: Introductionmentioning

confidence: 99%

“…To the best of our knowledge, there is no report of such amphiphilic block copolymers. To synthesize such polyketal based block copolymers, poly( N ‐vinyl pyrrolidone) (PNVP) can be very suitable hydrophilic polymeric segment owing to its high biocompatibility, stability and stress resistivity towards external stimuli like peroxide, UV irradiation, ultrasound, temperature etc ,,,…”

Section: Introductionmentioning

confidence: 99%

“…So, here in, we report for the first time, the synthesis of acid‐degradable hydrophobic alkyne‐terminated aliphatic polyketal copolymer having no carboxylic or, amide linkages and thereof the synthesis of novel double hydrophilic amphiphilic block copolymer via alkyne‐azide click reaction with azide‐terminated poly( N ‐vinylpyrrolidone), a reportedly biocompatible hydrophilic segment,,, suitable for site specific pH‐responsive drug delivery. Further, we have shown the fabrications of nano‐sized polymeric micelles from the self assembly of this novel block copolymer and the corresponding anticancer drugs doxorubicine and imatinib‐loaded micelles.…”

Section: Introductionmentioning

confidence: 99%

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In Vitro Anticancer Drug Delivery Using Amphiphilic Poly(N‐vinylpyrrolidone)‐b‐Polyketal‐b‐Poly(N‐vinylpyrrolidone) Block Copolymer as Micellar Nanocarrier

et al. 2018

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We have first synthesized acid‐degradable alkyne‐terminated aliphatic polyketal and thereof synthesized novel pH‐responsive double hydrophilic amphiphilic block copolymer of poly(N‐vinyl pyrrolidone) (PNVP) and aliphatic polyketal (PK) (PNVP‐b‐PK‐b‐PNVP via click chemistry upon reaction with azide‐terminated PNVP. Formation of block copolymer is confirmed by proton nuclear magnetic resonance, gel permeation chromatography, thermogravimetry, differential scanning calorimetry, and fluorescence spectroscopy techniques. pH‐dependent degradation study of the block copolymer shows faster degradation at lower pH. Transmission electron microscopy (TEM) has revealed the formation of tiny (∼3.8 nm) micellar nanoparticles. Loading of the anticancer drugs doxorubicin (Dox) and imatinib in the micelle is confirmed from UV‐Visible, and TEM studies. Drug release study from drug‐loaded micelles has shown that imatinib is being released faster than Dox and both systems have shown higher load release at acidic pH of 6.4. Doxorubicin‐ and imatinib‐ loaded micelles demonstrate significant tumoricidal properties against parental and drug resistant human erythroleukemia K‐562 and Dalton's lymphoma cells with respect to enhanced cellular uptake, cytotoxicity and growth inhibition.

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Synthesis and Analysis of Well‐Defined Copolymers via by Combination ROP Technique

Yildiko,

Tanriverdi,

Ata

et al. 2023

Macro Reaction Engineering

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Herein, the PCL‐PEG‐PCL macro xanthate reversible addition−fragmentation chain‐transfer agent was obtained on the polyethylene glycol (PEG) (600, 1000, and 1500 g/mol) block, after the addition of ɛ‐caprolactone via ring‐opening polymerization. Then, Poly (Styrene‐b‐ԑ‐Caprolactone‐b‐PEG‐b‐ԑ‐Caprolactone‐b‐Styrene) pentablock copolymer was synthesized RAFT solution polymerization technique via mediated PCL‐PEG‐PCL xanthate macro‐RAFT agents and 2,2′‐azobisisobutyronitrile as initiator. The products were demonstrated using Fourier transform infrared spectrophotometer (FT‐IR), proton nuclear magnetic resonance (1H‐NMR), carbon nuclear magnetic resonance (13C‐NMR), differential scanning calorimetry (DSC), and gel permeation chromatography (GPC) analyses. First‐order linear kinetic graphs of the reaction mechanism were observed with an increase in molecular weights (MW) between 16 000 and 36 000 g/mol. The narrow dispersity (Đ = 1.40 – 1.48) polymer formation of styrene (St) controlled by RAFT polymerization confirms the increase in molecular weight according to the polymerization time. The reaction kinetics were first order and the rate constants were found to be k1 = 6.16 × 10−4s−1, k2 = 6.91 × 10−4s−1 and k3 = 7.33 × 10−4s−1. Thermal and spectroscopic analyzes prove that the reactions were carried out successfully.This article is protected by copyright. All rights reserved

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Synthesis of well-defined amphiphilic poly(d,l-lactide)-b-poly(N-vinylpyrrolidone) block copolymers using ROP and xanthate-mediated RAFT polymerization

Cited by 39 publications

References 46 publications

Synthesis and characterization of polystyrene-block-poly(vinylbenzoic acid): a promising compound for manipulating photoresponsive properties at the nanoscale

Synthesis and characterization of polystyrene-block-poly(vinylbenzoic acid): a promising compound for manipulating photoresponsive properties at the nanoscale

In Vitro Anticancer Drug Delivery Using Amphiphilic Poly(N‐vinylpyrrolidone)‐b‐Polyketal‐b‐Poly(N‐vinylpyrrolidone) Block Copolymer as Micellar Nanocarrier

Synthesis and Analysis of Well‐Defined Copolymers via by Combination ROP Technique

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