Synthesis of zwitterionic acrylamide copolymers for biocompatible applications

Abstract

In order to prepare acrylamide copolymers with non-toxicity for environment-friendly materials, a series of zwitterionic acrylamide copolymers with varying acrylamide content were synthesized with DMAPS (3-dimethyl (methacryloyloxyethyl) ammonium propane sulfonate) and acrylamide via free radical polymerization. The structural properties and cytotoxicity are carefully investigated. The results demonstrate that DMAPS-co-acrylamide copolymers contain DMAPS and acrylamide segments that form a matrix consisting of strong electrostatic interactions as well as strong hydrogen bonding. DMAPS segments exhibit negligible influence on the glass phase transition behavior, yet affect the composite's water-contact angle. The optimum hydrophilic properties are obtained by adjusting the acrylamide content to 50 wt%. All DMAPS-co-acrylamide copolymers are measured to be non-toxic. The DMAPS segments allow for suitable contribution to the biocompatibility of the synthesized copolymer, in which copolymers containing higher DMAPS content demonstrate better biocompatibility.

Zwitterionic Sulfobetaine Hydrogel Electrolyte Building Separated Positive/Negative Ion Migration Channels for Aqueous Zn‐MnO2 Batteries with Superior Rate Capabilities

“…These results confirm the biocompatibility of the ZSC‐gel, consistent with the pioneering investigations on zwitterionic polymers. [ 29,30 ]…”

One-Step Preparation of Zwitterionic-Rich Hydrophilic Hydrothermal Carbonaceous Materials for Enrichment of N-Glycopeptides

“…40 As for HTC-Glc-3%MSA, the sulfobetaine structure was confirmed by the presence of −SO 3 at around 1043 cm −1 and −N + (CH 3 ) 2 − at around 960 cm −1 in MSA (Figure 4e) and HTC-Glc-3%MSA (Figure 4d) according to the previously reported literature. 41,42 At the same time, the above peaks did not appear in HTC-Glc (Figure 4b), also confirming the successful grafting of two kinds of zwitterionic groups.…”

“…Comparing the FT-IR spectra of MPC (Figure c), HTC-Glc (Figure b), and HTC-Glc-10%MPC (Figure a), we also could see the peaks at around 1240 and 1080 cm –1 in MPC and HTC-Glc-10%MPC corresponding to the stretching vibration of PO and the stretching vibration of −POCH 2 –, as well as the peaks at around 1170 and 970 cm –1 corresponding to the stretching vibration of C–N and N + (CH 3 ) 3 . As for HTC-Glc-3%MSA, the sulfobetaine structure was confirmed by the presence of −SO 3 at around 1043 cm –1 and −N + (CH 3 ) 2 – at around 960 cm –1 in MSA (Figure e) and HTC-Glc-3%MSA (Figure d) according to the previously reported literature. , At the same time, the above peaks did not appear in HTC-Glc (Figure b), also confirming the successful grafting of two kinds of zwitterionic groups.…”

Development of Antimicrobial and Antifouling Universal Coating via Rapid Deposition of Polydopamine and Zwitterionization

“…In addition, it was reported that pDA coatings attenuated the toxicity effect of semiconductor quantum dots in blood and enhanced blood compatibility of materials . SB-related materials have been applied for the medical applications due to their high biocompatibility. , Accordingly, the released copper ions from the coatings cause negligible cytotoxicity, and the coatings can be regarded as biocompatible materials for medical applications.…”

“…48 SB-related materials have been applied for the medical applications due to their high biocompatibility. 49,50 Accordingly, the released copper ions from the coatings cause negligible cytotoxicity, and the coatings can be regarded as biocompatible materials for medical applications.…”