“…Our continuing interest in the chemistry of 1,2,3-triazoles [ 63 , 64 , 65 , 66 , 67 ] and the importance of trifluoromethyl-substituted 1,2,3-triazoles encouraged us to evaluate the possibility of performing click reactions of 3,3,3-trifluoropropyne (TFP) with aryl- and alkyl-azides under mild and practical conditions. In contemplating possible methods to carry out these click reactions, we recognized that 2-bromo-3,3,3-trifluoropropylene (BTP) is a commercially available reagent [ 68 , 69 , 70 , 71 , 72 ], and that its [3+2]-cycloaddition reactions have been employed to produce CF 3 -substituted pyrazoles [ 73 , 74 , 75 , 76 ], -isoxazoles [ 77 ] and -pyrroles [ 78 ]. Particularly informative are the observations that BTP can be readily transformed to TFP by treatment with bases [ 79 , 80 , 81 , 82 , 83 ] like i -Pr 2 NLi and 1,8-diazabicyclo[5.4.0]undec-7-ene DBU, and that compared to gaseous TFP, BTP is an inflammable, storage-stable and easily handled liquid.…”