Synthesis of α-PNA containing a functionalized triazine as nucleobase analogue

Bartolami, Eline; Gilles, Arnaud; Dumy, Pascal; Ulrich, Sébastien

doi:10.1016/j.tetlet.2015.03.072

Cited by 2 publications

(1 citation statement)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The synthetic possibilities for the formation of alternative scaffolds bearing nitrogenous bases are virtually limitless. The development and study of hybridization properties of so-called peptide NAs built both on the classic aminoethyl glycine motif [169], as well as on the basis of dipeptide structures [170] and conformationally constrained analogs [171], has outgrown into a separate research area. In addition, combinations of the modifications described above allow one to obtain new types of oligonucleotides.…”

Section: Alternative Scaffolds For Nitrogenous Basesmentioning

confidence: 99%

A Visual Compendium of Principal Modifications within the Nucleic Acid Sugar Phosphate Backbone

Novikova,

Sagaidak,

Vorona

et al. 2024

Molecules

View full text Add to dashboard Cite

Nucleic acid chemistry is a huge research area that has received new impetus due to the recent explosive success of oligonucleotide therapy. In order for an oligonucleotide to become clinically effective, its monomeric parts are subjected to modifications. Although a large number of redesigned natural nucleic acids have been proposed in recent years, the vast majority of them are combinations of simple modifications proposed over the past 50 years. This review is devoted to the main modifications of the sugar phosphate backbone of natural nucleic acids known to date. Here, we propose a systematization of existing knowledge about modifications of nucleic acid monomers and an acceptable classification from the point of view of chemical logic. The visual representation is intended to inspire researchers to create a new type of modification or an original combination of known modifications that will produce unique oligonucleotides with valuable characteristics.

show abstract

Section: Alternative Scaffolds For Nitrogenous Basesmentioning

confidence: 99%