Synthesis, photophysical analysis, and in vitro cytotoxicity assessment of the multifunctional (magnetic and luminescent) core@shell nanomaterial based on lanthanide-doped orthovanadates

Abstract

Rare earths orthovanadates (REVO 4 ) doped with luminescent lanthanide ions (Ln 3? ) play an important role as promising light-emitting materials. Gadolinium orthovanadate exhibits strong absorption of ultraviolet radiation and as a matrix doped with Eu 3? ions is well known for its efficient and intense red emission, induced by energy transfer from the VO 4 3-groups to Eu 3? ions. In the presented study, Fe 3 O 4 @SiO 2 @GdVO 4 :Eu 3? 5 % nanomaterial was investigated. The core@shell structures demonstrate attractive properties, such as higher thermal stability, enhanced water solubility, increased optical response, higher luminescence, longer decay times, and magnetic properties. Silica coating may protect nanocrystals from the surrounding environment. Therefore, such silica-covered nanoparticles (NPs) are successfully utilized in biomedical research. Multifunctional magnetic nanophosphors are very interesting due to their potential biomedical applications such as magnetic resonance imaging, hyperthermic treatment, and drug delivery. Therefore, the aim of our study was to investigate photophysical, chemical, and biological properties of multifunctional REVO 4 doped with Ln 3? . Moreover, the studied NPs did not affect erythrocyte sedimentation rate, cell membrane permeability, and morphology of human red blood cells.

Preparation of Biocompatible, Luminescent-Plasmonic Core/Shell Nanomaterials Based on Lanthanide and Gold Nanoparticles Exhibiting SERS Effects

“…Lanthanide (Ln 3+ )-doped NPs are known to exhibit multicolor luminescence under UV or IR (up-conversion) excitation, depending on the type of activator ion used. − Their appealing spectroscopic properties are related to the 4f–4f transitions in Ln 3+ ions, resulting in narrow emission bands and long luminescence lifetimes (from tens of μs to several ms). , Moreover, such NPs can be resistant to high temperatures and photodegradation. Lanthanide-doped NPs can also form stable aqueous colloids, revealing typically negligible toxicity in various cell lines, an important feature for bioapplications. − In this field, fluoride-based NPs are particularly well-investigated, mostly because of their good properties as hosts for Ln 3+ activators and the availability of many efficient methods for their synthesis in the form of NPs. − …”

Influence of GdVO4:Eu3+ Nanocrystals on Growth, Germination, Root Cell Viability and Oxidative Stress of Wheat (Triticum aestivum L.) Seedlings

“…Wysoki ńska et al have reported that NaGdF 4 :Yb 3+ ,Er 3+ , NaGdF 4 or NaGdF 4 :Eu 3+ NPs may negatively affect the viability of macrophages and fibroblasts [39]. Our previous study conducted on LDNCs similar to those used in this study shown that Fe 3 O 4 @SiO 2 @GdVO 4 :Eu 3+ 5% core@shell type nanostructure had no effect on the erythrocyte sedimentation rate, morphology of red blood cells or their membrane permeability when present in concentrations up to 1 mg/mL [53]. However, our other research has shown that the effect of GdVO 4 :Eu 3+ 5% depends on the surface functionalization, kind of cells and concentration [54].…”

Influence of GdVO4:Eu3+nanocrystals on growth, germination, root cell viability and oxidative stress of wheat (Triticum aestivumL.) seedlings

“…Wysokińska et al have reported that NaGdF 4 :Yb 3+ ,Er 3+ , NaGdF 4 or NaGdF 4 :Eu 3+ NPs may negatively affect the viability of macrophages and fibroblast (39). Our previous study conducted on LDNCs similar to those used in this one has shown that Fe 3 O 4 @SiO 2 @GdVO 4 :Eu 3+ 5% core@shell type nanostructure had no effect on the erythrocyte sedimentation rate, morphology of red blood cells or their membrane permeability when present in concentrations up to 1 mg/mL (46).…”