Synthesis, Physical Characterization, Antibacterial and Antifungal activities of a novel bis(3-((E)-1-(2-hydroxyphenyl)ethylideneamino)phenyl)methanone

Abstract

Bis (3-((E)-1-(2-hydroxyphenyl) ethylideneamino) phenyl) methanone has been synthesized in this paper and its structure was confirmed by 1 H-NMR, 13C-NMR, IR and Mass spectra. Its AM1 and B3LYP/6-31G* calculations to characterize the physical properties of this molecule has been also presented. Finally, the antifungal and antibacterial activities of this derivative have been evaluated. IntroductionParticular attention has recently been paid to the synthesis and study of the diimino tetradentate Schiff bases and their complexes. This is due to their uses as biological models in understanding the structure of biomolecules and biological processes. The crucial role of Schiff bases in the biological function of bacteriorhodospin is proven. The retinal chromophore is bound covalently to the protein via a protonated Schiff base [1].Schiff-base ligands derived from 2-hydroxyacetophenone have been used as complexing agents [2]. In these ligands the electronic, steric and geometric effect of a methyl group on an imine carbon on asymmetric catalytic reactions can be investigated [3]. Salen type complexes are very well studied because this type of Schiff base ligands present suitable biometric properties that can mimic the structural feature of the active site [4].Based on these facts we decided to synthesize a new bis Schiff base derived from 2-hydroxyacetophenone.

Antioxidant, Antimicrobial Properties and In Silico Study of a N,N'-(ethane-1,2-diyl)bis(1-(9H-fluoren-2-yl)methanimine)

“…In this method, antioxidants oxidize the ABTS• + dark cation radical, resulting in a reduction of dark color. The color change that occurs with this reaction is used as a parameter for the measurement of antioxidant potential [31]. The scavenging effect on ABTS• + radical decreased in the order of Trolox (90.5%) > BHA(75.6%) > BHT(73.7%) > 1 (27%) is seen in Table 1.…”

“…The synthesis of Schiff bases and the measurement of their biological activities have long been of interest to researchers. It is seen that many studies have been conducted in the literature in this area [29,30] show antibacterial and antifungal properties, but this activity is greater with the addition of metal complexes [30,31]. The antibacterial activity of Schiff bases can be explained by the presence of keto-amine structure.…”