Synthesis, Physical Characterization of M(III) Transition Metal Complexes Derived from Thiodihydrazide and 5‐tert‐Butyl‐2‐hydroxy‐3‐(3‐phenylpent‐3‐yl) Benzaldehyde

Kumar, Gajendra; Johari, Rajeev; Devi, Shoma

doi:10.1155/2012/817051

Cited by 7 publications

(5 citation statements)

References 35 publications

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“…The serious medical problem of bacterial and fungal resistance and the rapid rate at which it develops has led to increasing levels of resistance to classical antibiotics [1,2,3], and the discovery and development of effective antibacterial and antifungal drugs with novel mechanisms of action have thus become urgent tasks for infectious disease research programs [4,5]. Coumarin and its derivatives represent one of the most active classes of compound possessing a wide spectrum of biological activity [6,7,8,9,10,11,12].…”

Section: Introductionmentioning

confidence: 99%

Antifungal Activities of New Coumarins

Al-Amiery

Kadhum²,

Mohamad³

2012

Molecules

109

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Abstract:Newly synthesized coumarins 4-((5-mercapto-4-phenyl-4H-1,2,4-triazol-3-yl)-methoxy)-2H-chromen-2-one and 4-((5-(phenylamino)-1,3,4-thiadiazol-2-yl)-methoxy)-2H-chromen-2-one were tested against selected types of fungi and showed significant activities. DFT calculations of the synthesized coumarins were performed using molecular structures with optimized geometries. Molecular orbital calculations provide a detailed description of the orbitals, including spatial characteristics, nodal patterns, and the contributions of individual atoms.

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Section: Introductionmentioning

confidence: 99%

Antifungal Activities of New Coumarins

Al-Amiery

Kadhum²,

Mohamad³

2012

Molecules

109

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“…The serious medical problem of bacterial and fungal resistance and the rapid rate at which it develops has led to increasing levels of resistance to classical antibiotics [2,3], and the discovery and development of effective antibacterial and antifungal drugs with novel mechanisms of action have thus become urgent tasks for infectious disease research programs [4]. Coumarins present a variety of bioactivities, including anticoagulant, estrogenic, dermal photosensitizing, antimicrobial, vasodilator, molluscicidal, antihelmintic, sedative and hypnotic, analgesic and hypothermic actions [5,6,7,8,9,10,11,12,13,14,15,16].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial and Antioxidant Activities of New Metal Complexes Derived from 3-Aminocoumarin

et al. 2011

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3-Aminocoumarin (L) has been synthesized and used as a ligand for the formation of Cr(III), Ni(II), and Cu(II) complexes. The chemical structures were characterized using different spectroscopic methods. The elemental analyses revealed that the complexes where M=Ni(II) and Cu(II) have the general formulae [ML2Cl2], while the Cr(III) complex has the formula [CrL2Cl2]Cl. The molar conductance data reveal that all the metal chelates, except the Cr(III) one, are non-electrolytes. From the magnetic and UV-Visible spectra, it is found that these complexes have octahedral structures. The stability for the prepared complexes was studied theoretically using Density Function Theory. The total energy for the complexes was calculated and it was shown that the copper complex is the most stable one. Complexes were tested against selected types of microbial organisms and showed significant activities. The free radical scavenging activity of metal complexes have been determined by measuring their interaction with the stable free radical DPPH and all the compounds have shown encouraging antioxidant activities.

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“…The discovery and evolution of beneficial antifungal and antibacterial [8]. drugs with novel action mechanisms have turned out to be serious duties for infectious disease research programs [9]. Coumarins present a variety of bioactivities, including estrogenic, dermal photosensitizing, antimicrobial, vasodilator, anticoagulant, molluscicidal, antihelmintic, sedative, and hypnotic, analgesic, and hypothermic actions.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Docking and Antimicrobial Activity of Some New Coumarin Incorporated Thiazole Derivatives

Kumar

Pai

2021

JPRI

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Synthesis and screening of a series of new coumarin derivatives coupled with thiazole are performed for their antimicrobial properties. A series of new thiazolyl coumarin derivatives were synthesized upon refluxing 3-bromoaceytl coumarin, substituted benzaldehyde and thiosemicarbazide in the presence of glacial acetic acid. Substituted 3-acetyl coumarin undergoes bromination in the presence of bromine and chloroform to form 3-Bromoaceytl coumarin. The thiazolyl coumarin derivatives were characterized based on IR, 1H NMR, and Mass spectral data. The docking studies have been carried out against the enzyme DNA gyrase (1KZN). Compound SCT 2 showed the highest docking score -5.662 compared to other compounds. The final synthesized compounds were screened for their antibacterial activity by tube dilution method. Compound SCT 1 and SCT 2 showed significant antibacterial activity with minimum inhibitory concentration of 12.5µg/ml and 6.25µg/ml, respectively, compared to standard Cephalosporin. The MIC results suggest that compounds SCT 1 and SCT 2 showed promising antibacterial activity. So these compounds are interesting lead molecules for further synthesis as antimicrobial agents.

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Synthesis, Physical Characterization of M(III) Transition Metal Complexes Derived from Thiodihydrazide and 5‐tert‐Butyl‐2‐hydroxy‐3‐(3‐phenylpent‐3‐yl) Benzaldehyde

Cited by 7 publications

References 35 publications

Antifungal Activities of New Coumarins

Antifungal Activities of New Coumarins

Antimicrobial and Antioxidant Activities of New Metal Complexes Derived from 3-Aminocoumarin

Synthesis, Docking and Antimicrobial Activity of Some New Coumarin Incorporated Thiazole Derivatives

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