Synthesis, Physico-chemical and Antimicrobial Studies on Metal (II) Complexes with Schiff Base Derived from Salicylaldehyde and 2,4-Dinitrophenylhydrazine

Mukhtar, Hayat M.; Sani, Umar; Shettima, U. A.

doi:10.9734/irjpac/2019/v19i230107

Cited by 4 publications

(3 citation statements)

References 6 publications

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“…This is also further confirmed by the shifting of amide ν(C=O) to lowering frequency by 5-50 cm -1 from 1625-1665 cm -1 in these complexes, suggesting the coordination of carbonyl oxygen atom to metal ions as such without experiencing the enolization. However, these bands are completely absent in Cr(III), Fe(III), and Zn(II) complexes, which confirmed the enol formation act in accordance with the coordination linkages to the metal ion after deprotonation [16,17]. Furthermore, the existence of coordinated water molecules was confirmed by the presence of non-ligand bands 820-850 cm -1 , which was further supported by the thermal analysis.…”

Section: Infrared Spectra and Bonding Modementioning

confidence: 54%

A heterocyclic N'-(4-(diethylamino)-2-hydroxybenzylidene)-4-oxopiperidine-1-carbohydrazide Schiff base ligand and its metal complexes: Synthesis, structural characterization, thermal behavior, fluorescence properties, and biological activities

Dongare

Aswar

2022

Eur J Chem

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A new heterocyclic hydrazone Schiff base ligand, N'-(4-(diethylamino)-2-hydroxy benzylidene)-4-oxopiperidine-1-carbohydrazide, (H2L) was derived by a condensation reaction of 4-oxopiperidine-1-carbohydrazide with 4-(diethylamino)-2-hydroxybenz-aldehyde. The ligand reacts with chloride salts of chromium(III), manganese(II), iron(III), cobalt(II), nickel(II), copper(II) and zinc(II) to form metal complexes of [Cr(L)(Cl)(H2O)2], [Mn(HL)(Cl)(H2O)2], [Fe(L)(Cl)(H2O)2], [Co(HL)(Cl)(H2O)2], [Ni(HL)(Cl)(H2O)2], [Cu(HL)(Cl) (H2O)2], [Zn(L)(H2O)], respectively. The structure of the hydrazone ligand was confirmed by elemental analysis and spectroscopic techniques, viz., FT-IR, 1H NMR, 13C NMR, and LC-MS spectroscopy. The newly synthesized ligand behaves as a tridentate ONO donor towards Cr, Mn, Fe, Co, Ni, Cu, and Zn metal ions. The spectral, magnetic moment, and thermal data indicate the octahedral geometry for all metal complexes except for Zn, which has tetrahedral geometry with 1:1 stoichiometry (M:L). ESR study revealed that π-bonding covalency is much stronger than the σ-bonding with axial distortion in the structure. The molar conductivity data suggested the nonelectrolytic nature of the complexes. The powder X-ray diffraction patterns suggest the nanocrystalline nature of the compounds. The SEM micrograph of the ligand significantly differs from its Ni(II) complex indicating coordination of Ni(II) ion to the ligand. The intense fluorescence emitted in the region of λExcitation 521 to 524 nm due to the functional fluorophores of the ligand and its manganese (II), chromium(III), cobalt(II), and zinc(II) complexes. Various kinetic parameters such as Ea, ∆S, ∆H, and ∆G of various decomposition steps were calculated from TGA diagrams using Coats-Redfern method and the thermal stability order was found to be Cr < Fe < Co < Mn = Cu < Zn < Ni. The antibacterial and antifungal activities of the ligand and its divalent and trivalent metal complexes were performed against the various pathogens viz. Escherichia coli, Salmonella typhi, Staphylococcus aureus, Bacillus subtilis, Candida albicans, and Aspergillus niger with reference to standard antibiotics viz. ofloxacin, azithromycin, and fluconazole. All metal complexes showed promising biological activity as compared with their parent ligand and may be used as a potential antimicrobial candidate in biological science.

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Section: Infrared Spectra and Bonding Modementioning

confidence: 54%

A heterocyclic N'-(4-(diethylamino)-2-hydroxybenzylidene)-4-oxopiperidine-1-carbohydrazide Schiff base ligand and its metal complexes: Synthesis, structural characterization, thermal behavior, fluorescence properties, and biological activities

Dongare

Aswar

2022

Eur J Chem

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“…19 Metal organic ligands (MOL) when allowed to react with metal ions result in the formation of mixed metal complexes. 24 Quantum mechanical methods have been used to show that the vanadyl complexes which have phenolate, alcoholate, carboxylate especially when these donors join a Schiff base donor, constitute the most stable complexes. 25 Schiff base complexes show a broad range of biological activities including antibacterial, antifungal, antiviral, antimalarial, anti-proliferate, anti-inflammatory, anti-cancer, anti-HIV, anti-helminthic and anti-pyretic.…”

Section: Introductionmentioning

confidence: 99%

A review of Titanium, Vanadium and Chromium transition metal Schiff base complexes with biological and catalytic activities

Assey

Mgohamwende

2020

PPIJ

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Schiff bases are compounds obtained from the condensation reaction of a primary amine and aldehyde or ketone. They can be coordinated with metals especially the transition metals to form Schiff base complexes. The objective of this work is to review the synthesis, biological as well as catalytic activities of both Schiff base ligands and their transition metal complexes of titanium, vanadium as well as chromium. The methodology used for looking for the references were through the internet. Biological activities that were considered in this review were mainly those of antibacterial and antifungal. For the antibacterial, both gram positive and gram negative strain were considered. The results obtained from the study indicated that the Schiff base complexes, Schiff bases as well as metal ions for the metals titanium, vanadium and chromium were used by different researchers to investigate antimicrobial activities against bacteria, fungi as well as anti-tumour activity against breast cancer. The antimicrobial literature studies showed that the metal ions were having lower inhibition capacity than the ligands but the complexes showed the highest inhibition capacity against the microbial. The use of Mono-and dioxide-vanadium (V) complexes showed anticancer activity against MCF-7 (breast cancer) cells. The cis-Dioxido vanadium (V) complexes were also investigated for catalytic activity on the oxidation of cyclohexane and gave conversion of 12% and selectivity of up to 85%. The paper is divided into five sections which include introduction, methodology used in looking for references, results and discussion, acknowledgements and references. The results obtained from the review show that the Schiff base complexes were more effective when screened as anti-microbial compounds than their ligands. The complexes also showed effectiveness when screened for their catalytic activity on organic chemistry reactions.

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“…It also showed no activity against all the selected fungal strains (Table 2). The results obtained in this study were not compared to any standard drug [54]. The reason for the improved antimicrobial activity of the synthesized complex can be attributed to the chelation theory [46].…”

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confidence: 96%

Iron–Imine Cocktail in Drug Development: A Contemporary Update

Anane,

Owusu,

Rivera

et al. 2024

IJMS

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Organometallic drug development is still in its early stage, but recent studies show that organometallics having iron as the central atom have the possibility of becoming good drug candidates because iron is an important micro-nutrient, and it is compatible with many biological systems, including the human body. Being an eco-friendly Lewis acid, iron can accept the lone pair of electrons from imino(sp2)-nitrogen, and the resultant iron–imine complexes with iron as a central atom have the possibility of interacting with several proteins and enzymes in humans. Iron–imine complexes have demonstrated significant potential with anticancer, bactericidal, fungicidal, and other medicinal activities in recent years. This article systematically discusses major synthetic methods and pharmacological potentials of iron–imine complexes having in vitro activity to significant clinical performance from 2016 to date. In a nutshell, this manuscript offers a simplistic view of iron complexes in medicinal inorganic chemistry: for instance, iron is presented as an “eco-friendly non-toxic” metal (as opposed to platinum) that will lead to non-toxic pharmaceuticals. The abundant literature on iron chelators shows that many iron complexes, particularly if redox-active in cells, can be quite cytotoxic, which can be beneficial for future targeted therapies. While we made every effort to include all the related papers, any omission is purely unintentional.

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Synthesis, Physico-chemical and Antimicrobial Studies on Metal (II) Complexes with Schiff Base Derived from Salicylaldehyde and 2,4-Dinitrophenylhydrazine

Cited by 4 publications

References 6 publications

A heterocyclic N'-(4-(diethylamino)-2-hydroxybenzylidene)-4-oxopiperidine-1-carbohydrazide Schiff base ligand and its metal complexes: Synthesis, structural characterization, thermal behavior, fluorescence properties, and biological activities

A heterocyclic N'-(4-(diethylamino)-2-hydroxybenzylidene)-4-oxopiperidine-1-carbohydrazide Schiff base ligand and its metal complexes: Synthesis, structural characterization, thermal behavior, fluorescence properties, and biological activities

A review of Titanium, Vanadium and Chromium transition metal Schiff base complexes with biological and catalytic activities

Iron–Imine Cocktail in Drug Development: A Contemporary Update

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