Synthesis, physicochemical properties, and biological activity of (acridinyl-9-thio)acetic acid hydrazides

Martynovskii, A. A.; Samura, B. A.; Omelyanchik, V. N.; Панасенко, О. І.; Omelyanchik, L. A.; Panasenko, Т. V.

doi:10.1007/bf00764993

Cited by 7 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The derivatives of hydrazides always show higher biological activities than amides; consequently, they are considered as an ideal and fully qualified alternative to amides. Hydrazide derivatives have been found as ubiquitous building blocks in fungicides, which exhibit antituberculosis, , antidepressant, insecticidal, anticonvulsant, antiviral, , anti-inflammatory, , anticancer, antifungal, − antibacterial, − and other − properties. For instance, RH-5849 is the first nonsteroidal ecdysone agonist that exhibited admirable activity against Drosophila via stimulating the ecdysteroid receptors (EcR) and inducing the molt of larva .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Structure–Activity Relationship, and Mechanism of a Series of Diarylhydrazide Compounds as Potential Antifungal Agents

Liu

et al. 2023

J. Agric. Food Chem.

View full text Add to dashboard Cite

A series of simple diarylhydrazide derivatives (45 examples) were well-designed, prepared, and screened for their antifungal activities both in vitro and in vivo. Bioassay results suggested that all designed compounds had significant activity against Alternaria brassicae (EC 50 = 0.30−8.35 μg/mL). Among of them, 2c, as the highest activity compound, could effectively inhibit the growth of plant pathogens Pyricularia oryza, Fusarium solani, Alternaria solani, Alternaria brassicae, and Alternaria alternate and was more potent than carbendazim and thiabendazole. 2c showed almost 100% protection at 200 μg/mL in vivo activity against A. solani in tomato. Moreover, 2c did not affect the germination of cowpea seed and the growth of normal human hepatocytes. The preliminary mechanistic exploration documented that 2c could result in the abnormal morphology and irregular structure of the cell membrane, destroy the function of mitochondria, increase the reactive oxygen species, and inhibit the proliferation of hypha cell. The above results manifested that target compound 2c could be a potential fungicidal candidate against phytopathogenic diseases for its excellent fungicidal activities.

show abstract

Section: Introductionmentioning

confidence: 99%

Synthesis, Structure–Activity Relationship, and Mechanism of a Series of Diarylhydrazide Compounds as Potential Antifungal Agents

Liu

et al. 2023

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

“…They were found to possess antimicrobial and antibacterial [ [7][8][9][10], antidepressant [11], anti-HCV and anticancer [12,13], anti-helmintic [14], antioxidant [15], anti-proliferative [16], microbicidal and insecticidal [17] activities. Hydrazides of (acridinyl-9-thio) acetic acid [18] being moderately toxic showed a variety of therapeutic properties, viz. neurotropic, anti-inflammatory, analgesic, anti-microbial and fungistatic effects.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and investigation of antibacterial activity of 1-(4-substituted phenyl)-5-oxopyrrolidine-3-carbohydrazide derivatives

Plaga,

Sapijanskaitė-Banevič,

Vaickelionienė

2023

chemija

View full text Add to dashboard Cite

Hydrazides are very important precursors for the synthesis of a wide variety of derivatives, including heterocyclic compounds of biological interest in drug design and discovery. Acid hydrazides with a pyrrole, thiophene, furan, quinoline, isoquinoline, isoxazole and benzimidazole core in the structure were found to be used in medicine, pharmacy, agriculture and many other fields. In the search for compounds with antibacterial properties, mono- and dihydrazides were used in this study to prepare 1-(4-substituted phenyl)-5-oxopyr-rolidine-3-carbohydrazide derivatives bearing the corresponding hydrazone and azole substituents. The formation of the target compounds was performed via condensation reactions with the chosen aromatic aldehydes and isatin, which led to the construction of the appropriate hydrazone-type structures as well as with diketones which afforded compounds with pyrazole and pyrrole nuclei. In addition, a preliminary antibacterial evaluation of the synthesised compounds was performed using the gram-positive Bacillus subtilis and the gramnegative Escherichia coli bacterial strains. As it was expected, the evaluation revealed potential antibacterial candidates that can help address the global challenges of antibiotic resistance and infectious disease outbreaks.

show abstract

“…They can be employed for the treatment of diseases of bones and joints, gastrointestinal tract, liver, cardiovascular and urogenital systems, autoimmune and allergic disorders, skin and oncological diseases . Sulfur‐containing acids (Y = S) also exhibit a high and diverse pharmacological activity …”

Section: Introductionmentioning

confidence: 99%

New atranes and similar ionic complexes. Synthesis, structure, properties

Адамович

2019

Applied Organom Chemis

View full text Add to dashboard Cite

show abstract

Synthesis, physicochemical properties, and biological activity of (acridinyl-9-thio)acetic acid hydrazides

Cited by 7 publications

References 0 publications

Synthesis, Structure–Activity Relationship, and Mechanism of a Series of Diarylhydrazide Compounds as Potential Antifungal Agents

Synthesis, Structure–Activity Relationship, and Mechanism of a Series of Diarylhydrazide Compounds as Potential Antifungal Agents

Synthesis and investigation of antibacterial activity of 1-(4-substituted phenyl)-5-oxopyrrolidine-3-carbohydrazide derivatives

New atranes and similar ionic complexes. Synthesis, structure, properties

Contact Info

Product

Resources

About