Synthesis, properties and structure of some bithiophene complexes of chromium, tungsten, manganese and iron

Abstract

The Rh Vaska-type complexes, trans-[Rh(CO)(Cl)(YR3)] (Y=Group 15 atom; R=aryl or alkyl), analogues of the well-known Vaska's complex, trans-[Ir(CO)(Cl)(PPh3)], are well behaved model systems for various catalytic systems. They readily undergo a variety of reactions e.g., iodomethane oxidative addition, typically forming alkyl species as intermediates, e.g., [Rh(Cl)(CO)(CH3)(I)(YR3) ~], reductive elimination, substitution, insertion, etc.

Asymmetric total synthesis of the indole alkaloid cyclopiazonic acid and first structure–activity data

“…Additionally, spectroscopic data of CPA (1) and isoCPA (17) were identical with those already published. 21,22 In order to evaluate the significance of the acyl tetramic acid moiety for SERCA inhibition two series of CPA derivatives were prepared. In the first series the acetyl group was replaced for larger acyl residues, such as cyclopropyl, benzyl and phenyl by acylation of the cyclization product 13 with the corresponding acyl Meldrum's acids, which were prepared according to literature procedures.…”