Synthesis, pulse radiolysis, and in vitro radioprotection studies of melatoninolipoamide, a novel conjugate of melatonin and α-lipoic acid

Venkatachalam, S. R.; Salaskar, Avinash; Chattopadhyay, Angshuman; Barik, Atanu; Mishra, Beena; Gangabhagirathi, R.; Priyadarsini, K. Indira

doi:10.1016/j.bmc.2006.05.042

Cited by 33 publications

(13 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This compound named melatoninolipoamide was used to carry out pulse radiolysis study. The results indicate that melatonin moiety of the conjugate reacts preferably with oxidizing radicals, and the lipoic acid moiety exhibits preferential reaction with reducing radicals [71]. Thus, our rationale behind the choice of melatonin and ALA was essentially to quench all forms of free radicals leading to overall protection of myocardium.…”

Section: Resultsmentioning

confidence: 96%

A Combination of Melatonin and Alpha Lipoic Acid has Greater Cardioprotective Effect than Either of them Singly Against Cadmium-Induced Oxidative Damage

et al. 2010

View full text Add to dashboard Cite

Present study evaluates cardioprotective role of melatonin (Mel), alpha lipoic acid (ALA), a combination of melatonin and alpha lipoic acid (Mel + ALA) against cadmium (Cd)-induced oxidative damage. Female albino rats were subjected to 15-day exposure to Cd (5.12 mg/kg bw) alone or treated with ML (10 mg/kg bw) + ALA (25 mg/kg bw) simultaneously. Plasma markers of cardiac damage, cardiac free radical generation, lipid peroxidation, endogenous antioxidant status, cadmium load, metallothionein induction, and histopathology were evaluated in various experimental groups. Combination of Mel + ALA significantly prevented leakage of marker enzymes of cardiac damage, changes in cardiac free radical generation, endogenous antioxidants, antioxidant status, structural alterations and augmented the degree of metallothionein (MT) induction. The results demonstrate that ML + ALA co-administration effectively protected against Cd-induced cardiac oxidative damage.

show abstract

Section: Resultsmentioning

confidence: 96%

A Combination of Melatonin and Alpha Lipoic Acid has Greater Cardioprotective Effect than Either of them Singly Against Cadmium-Induced Oxidative Damage

et al. 2010

View full text Add to dashboard Cite

show abstract

“…It was found that the melatonin moiety of the conjugate reacts preferably with oxidizing radicals and the LA moiety exhibits preferential reaction with reducing radical. Using c-radiation induced lipid peroxidation in liposomes and hemolysis of erythrocytes as a model, the radioprotection ability was compared with those of melatonin and LA and the results suggest that the conjugate can be explored as a probable radioprotector [97].…”

Section: Antioxidant Defensementioning

confidence: 99%

“…The conjugate was named melatoninolipoamide [97]. It was found that the melatonin moiety of the conjugate reacts preferably with oxidizing radicals and the LA moiety exhibits preferential reaction with reducing radical.…”

Section: Antioxidant Defensementioning

confidence: 99%

The Effects and Mechanisms of Mitochondrial Nutrient α-Lipoic Acid on Improving Age-Associated Mitochondrial and Cognitive Dysfunction: An Overview

2007

View full text Add to dashboard Cite

We have identified a group of nutrients that can directly or indirectly protect mitochondria from oxidative damage and improve mitochondrial function and named them "mitochondrial nutrients". The direct protection includes preventing the generation of oxidants, scavenging free radicals or inhibiting oxidant reactivity, and elevating cofactors of defective mitochondrial enzymes with increased Michaelis-Menten constant to stimulate enzyme activity, and also protect enzymes from further oxidation, and the indirect protection includes repairing oxidative damage by enhancing antioxidant defense systems either through activation of phase 2 enzymes or through increase in mitochondrial biogenesis. In this review, we take alpha-lipoic acid (LA) as an example of mitochondrial nutrients by summarizing the protective effects and possible mechanisms of LA and its derivatives on age-associated cognitive and mitochondrial dysfunction of the brain. LA and its derivatives improve the age-associated decline of memory, improve mitochondrial structure and function, inhibit the age-associated increase of oxidative damage, elevate the levels of antioxidants, and restore the activity of key enzymes. In addition, co-administration of LA with other mitochondrial nutrients, such as acetyl-L: -carnitine and coenzyme Q10, appears more effective in improving cognitive dysfunction and reducing oxidative mitochondrial dysfunction. Therefore, administrating mitochondrial nutrients, such as LA and its derivatives in combination with other mitochondrial nutrients to aged people and patients suffering from neurodegenerative diseases, may be an effective strategy for improving mitochondrial and cognitive dysfunction.

show abstract

“…3 Using this approach, several research groups have recently designed and synthesized hybrid molecules by coupling LA with other bioactive molecules. These efforts resulted in new molecules with antioxidant activity hyphenated with a wide variety of other activities such as: protection against reperfusion arrhythmias, 4,5 nitric oxide synthase inhibition, 6 erythrocyte protection from hemolysis, 7 antiproliferative activity, 8,9 acetylcholinesterase inhibition, 10 butyrylcholinesterase inhibition, 11 as well as radioprotective, 12 and anti-inflammatory activity. 13,14 Moreover, combination of 1,2-dithiolane-3-alkyl group with the catechol moiety through five-membered heterocyclic rings, as bioisosters, 15 of the amide bond led to compounds which exhibited strong neuroprotective activity.…”

Section: Introductionmentioning

confidence: 99%

Design and synthesis of novel neuroprotective 1,2-dithiolane/chroman hybrids

Koufaki

Kiziridi

Alexi

et al. 2009

Bioorganic & Medicinal Chemistry

View full text Add to dashboard Cite

Synthesis, pulse radiolysis, and in vitro radioprotection studies of melatoninolipoamide, a novel conjugate of melatonin and α-lipoic acid

Cited by 33 publications

References 23 publications

A Combination of Melatonin and Alpha Lipoic Acid has Greater Cardioprotective Effect than Either of them Singly Against Cadmium-Induced Oxidative Damage

A Combination of Melatonin and Alpha Lipoic Acid has Greater Cardioprotective Effect than Either of them Singly Against Cadmium-Induced Oxidative Damage

The Effects and Mechanisms of Mitochondrial Nutrient α-Lipoic Acid on Improving Age-Associated Mitochondrial and Cognitive Dysfunction: An Overview

Design and synthesis of novel neuroprotective 1,2-dithiolane/chroman hybrids

Contact Info

Product

Resources

About