Synthesis, radioiodination and in vivo evaluation of ethyl 1,4-dihydro-7-iodo-4-oxoquinoline-3-carboxylate as a potential pulmonary perfusion scintigraphic radiopharmaceutical

Sakr, Tamer M.; Motaleb, M. A.; Zaghary, Wafaa A.

doi:10.1007/s10967-014-3299-3

Cited by 14 publications

(2 citation statements)

References 43 publications

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“…Being a tissue‐rich with angiotensin II receptor subtype II, the kidney showed high‐radioactivity uptake and low clearance augmented by low‐water solubility of 125 I‐CAN, equal to 5, 13, 30, and 21 at 5, 15, 30, and 60 minutes, respectively. A similar profile between liver and intestine was observed indicating some enterohepatic circulation . Results of the radioactive uptake of both kidney and liver are compatible with data published by Sidiqui et al who mentioned that the main elimination route of mother drug CAN is through hepatobiliary and urinary pathways .…”

Section: Resultssupporting

confidence: 89%

Radioiodination and biological evaluation of candesartan as a tracer for cardiovascular disorder detection

Sanad

Sallam

Marzook

et al. 2016

Labelled Comp Radiopharmac

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The goal of the study aims to evaluate newly radioiodinated candesartan (CAN) as a potential cardiovascular tracer. CAN was labeled using I with chloramine-T (Ch-T) and N-bromosuccinimide (NBS) with full characterization of cold Iodo-candesartan. Factors such as pH, reaction temperature, reaction time, substrate, and oxidizing agent amounts were studied to optimize the radioiodination of CAN. The optimum radiochemical yield of I-CAN was 98%. The labeled compound was separated and purified using high-pressure liquid chromatography. The biological distribution indicates the suitability of I-CAN as a novel tracer to detect cardiovascular disorders.

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Section: Resultssupporting

confidence: 89%

Radioiodination and biological evaluation of candesartan as a tracer for cardiovascular disorder detection

Sanad

Sallam

Marzook

et al. 2016

Labelled Comp Radiopharmac

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“…Uptake of radioactivity in each organ was measured using a gamma counter and expressed as percent injected dose per gram (% ID/gram ± S.D.) [56,57]. One-way ANOVA test (P<0.05) was used to evaluate data and all the results were given as mean ± SEM.…”

Section: Biodistribution Study Of 99m Tc-dox-egcg-aunpsmentioning

confidence: 99%

Preparation, Characterization, Cytotoxicity and Biological Evaluation of <sup>99m</sup>Tc-Doxorubicin-Epigallocatechingallate Functionalized Gold Nanoparticles as a New Generation of Theranostic Radiopharmaceutical

Sakr¹,

Morsy²,

Na³

et al. 2018

Preprint

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Gold nanoparticles are currently used for the treatment of cancer through a myriad of modalities and delivery approaches. Conjugation of tumor imaging Single Photon Emitting Computed Tomographic (SPECT) radiopharmaceutical to gold nanoparticles will allow systemic targeting and imaging of cancer tissues simultaneously. In this study, gold nanoparticles (AuNPs) were prepared using Epigallocatechingallate (EGCG), loaded with doxorubicin (Dox), and characterized before and after doxorubicin conjugation. Cytotoxicity of EGCG-AuNPs and Dox-EGCG-AuNPs were evaluated against breast carcinoma (MCF-7) and hepatocellular carcinoma (HepG-2) cell lines demonstrating high cytotoxic effects of Dox-EGCG-AuNPs against both cell lines. Doxorubicin was radiolabeled with 99mTc and our new approach has optimized various labeling conditions resulting in a radiochemical yield of 93.5 ± 2.04%. Biodistribution of 99mTc-Dox-EGCG-AuNPs was studied in normal and tumor bearing mice following I.V. and intratumoral injections at different time intervals. Results showed high uptake of the intravenously injected 99mTc-Dox-EGCG-AuNPs in tumor tissue (22.45 %ID/g at 2 h). In addition, localized intratumoral injection of 99mTc-Dox-EGCG-AuNPs showed extremely high levels of uptake in tumor (80.22 %ID/g at 15 min) with high retention for extended periods post injection. Our results present prospects for the utility of 99mTc-Dox-EGCG-AuNPs as a multiplexed theranostic agent through SPECT imaging of tumor tissue and therapy through photothermal destruction of cancer tissue through the application of exogenous laser lights as well as through tyrosine phosphatases inhibitor (through EGCG), and topoisomerase II inhibitor (through doxorubicin) effects.

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Nano-titania: a novel purification and concentration adsorbent for 125I production for medical uses

Sakr

Fasih

Amin

2017

J Radioanal Nucl Chem

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Synthesis, radioiodination and in vivo evaluation of ethyl 1,4-dihydro-7-iodo-4-oxoquinoline-3-carboxylate as a potential pulmonary perfusion scintigraphic radiopharmaceutical

Cited by 14 publications

References 43 publications

Radioiodination and biological evaluation of candesartan as a tracer for cardiovascular disorder detection

Radioiodination and biological evaluation of candesartan as a tracer for cardiovascular disorder detection

Preparation, Characterization, Cytotoxicity and Biological Evaluation of <sup>99m</sup>Tc-Doxorubicin-Epigallocatechingallate Functionalized Gold Nanoparticles as a New Generation of Theranostic Radiopharmaceutical

Nano-titania: a novel purification and concentration adsorbent for 125I production for medical uses

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