Synthesis, Reactions and Antibacterial Activity of 3-Acetyl[1,2,4]triazolo[3,4-a]isoquinoline Derivatives using Chitosan as Heterogeneous Catalyst under Microwave Irradiation

Synthesis and Antimicrobial Activity of Some New Pyrazoles, Fused Pyrazolo[3,4-d]-pyrimidine and 1,2-Dihydroimidazo-[2,1-c][1,2,4]triazin-6-one Derivatives

“…The synthesis of pyrazolo[3,4- d ]-pyrimidine derivatives has also received significant attention in recent years because of their wide range of biological and pharmaceutical properties such as antitumor and antileukemia activity [ 13 ], anti-mycobacterial [ 14 ] and antidiabetic [ 15 , 16 , 17 ] agents, kinase [ 18 , 19 ] and phosphodiesterase [ 20 ] inhibitors, and also for their valuable antiangiogenic [ 21 ], fungicidal [ 22 ], cytotoxic [ 23 ] antitubercular [ 24 ], antimicrobial [ 25 ], potent antiproliferative agent [ 26 ] and anthelmintic [ 27 ] activities. In view of the above mentioned findings and as continuation of our effort [ 28 , 29 , 30 , 31 ] to identify new candidates that may be of value in designing new, potent, selective and less toxic antimicrobial agents, we report in the present work the synthesis of some new pyrazoles, pyrazolo[3,4- d ]pyrimidine- and imidazo[2,1-c][1,2,4]triazinone derivatives starting from 2-hydrazinyl-4,4-diphenyl-1 H -imidazol-5(4 H )-one in order to investigate their antimicrobial activity.…”

Synthesis, Cytotoxicity and Docking Simulation of Bioactive [1,2,4]Triazolo[3,4-α]dihydroisoquinoline Chalcone Derivatives

“…[24][25][26][27][28] Also, [l, 2,4]triazolo [3,4-a]isoquinolines showed pharmacological activities that include anti-inflammatory, antidepressant, and cardiovascular. 29 In continuation of our work in the synthesis of the bioactive heterocyclic compounds, 6,[30][31][32] we report herein the synthesis of new chalcones incorporating both [l,2,4]triazolo [3,4-a]isoquinolines and pyrazoles moieties.…”

Facial Regioselective Synthesis of Novel Bioactive Spiropyrrolidine/Pyrrolizine-Oxindole Derivatives via a Three Components Reaction as Potential Antimicrobial Agents

“…In particular, azomethineylides have been used to synthesize pyrrolidines and pyrrolizines with various substitutions, allowing the introduction of several functional groups in a single operation [ 15 ]. As part of our own interest in the synthesis of biologically active heterocyclic compounds [ 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ], we report an efficient methodology for the synthesis of novel spirooxindole-spiropiperidinone-pyrrolidine and spirooxindole-spiropiperidinone-pyrrolizine derivatives, and investigate their antimicrobial activities.…”