Synthesis, Reactions and Antimicrobial Activity of Some New Indolyl‐1,3,4‐Oxadiazole, Triazole and Pyrazole Derivatives

Abstract

Indole‐3‐carboxylic acid hydrazide 3 was prepared and was treated with aromatic aldehydes in ethanol to give the corresponding hydrazone derivatives 4–7 in good yields. The indole carbohydrazide was incorporated into the 3‐indolyloxadiazoles 8–11 and 18, 3‐indolyltriazoles 13–17 and 35, 3‐indolylpyrazole derivatives 19–23 and carbamate derivatives 26–27. Furthermore, interaction of the carboazide 24 with hydrazine hydrate in refluxing toluene afforded the corresponding semicarbazide derivative 30. The thiadiazine derivative 34 was also prepared. Some of these compounds were screened in vitro for their antibacterial and antifungal activity.

Synthesis of Some New Pyrimidines and Pyrrolo [2,3-d] Pyrimidines as Potential Antimicrobial Agents

“…Furthermore, reaction of (2) with ethyl chloroacetate in dimethyl formamide in presence of potassium carbonate anhydrous (10) leads to the formation of Ethyl -7H-pyrrolo [2,3-d] pyrimidin-7-ylacetate (6).…”

3-Phenoxymethyl-6-phenyl-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole

“…N-Bridged heterocycles derived from 1,2,4-triazoles have applications in medicine, agriculture and industry (Farghaly et al, 2006). Heterocycles bearing a triazole or 1,3,4thiadiazole moiety are reported to show a wide spectrum of biological activity (Suresh Kumar et al, 2010;Mallikarjuna et al, 2009) such as anti-bacterial (Abdel-Rahman & Farghaly, 2004), anti-aggregator agents (Czarnocka-Janowicz et al, 1991), anti-viral (Srivastava et al, 1991) and anti-inflammatory (Unangst et al, 1992) activities.…”

1-[2-(3,4-Dichlorophenyl)-5-(3,4,5-trimethoxyphenyl)-2,3-dihydro-1,3,4-oxadiazol-3-yl]ethanone

“…Dao-Hang He and Yong-Chuang Zhu S1. Comment 1,3,4-Oxadiazole derivatives are well known to possess a diverse range of bioactivities in the pharmaceutical and agrochemical fields; these include insecticidal, antibacterial, anticancer, and anti-inflammatory activities (Abdel et al, 2003;Abdel-Rahman & Farghaly, 2004;Chai et al, 2002;Mohd et al, 2004). Here we report the synthesis and crystal structure of a 1,3,4-oxadiazole derivative containing the 3,4,5-trimethoxyphenyl unit (Fig.…”