Synthesis, reactions, and applications of fluorine-containing multifunctional carbon compounds

Access to Multifunctionalized Tetrasubstituted Carbon Centers Bearing up to Three Different Heteroatoms via Tandem Geminal Chlorofluorination of 1,2-Dicarbonyl Compounds

“…Even further, the introduction of three different heteroatoms on the same carbon would greatly increase the potential of functional diversity. However, such complex heteroatom-rich carbon centers are hard to access because of the often poor compatibility among heteroatoms and/or the challenges associated with chemoselectivity control.…”

A Facile Synthesis of Two Series of Multifunctional Carbon Compounds from α,α-Dihalo Ketones Using Allylsamarium Bromide

“…Compounds containing a carbon atom bearing three or four different labile functional groups are categorized as multifunctional carbon compounds. [2][3][4] These compounds should be of considerable significance in theoretical and synthetic organic chemistry. But little attention has been paid to the synthesis of homoallylic alcohols containing other attractive functional groups utilizing these methods via multifunctional carbonyl compounds.…”

A Facile One-Pot Synthesis of α-Halo-α-allyl-aldehydes from α,α-Dihaloketones Using Allylsamarium Bromide and DMF

“…2 Organic compounds containing three or four different labile functional groups are categorized as multifunctional carbon compounds. 3 Therefore, a-halo-a-allyl aldehydes may be called trifunctional carbon compounds. These aldehydes have three active functional groups that can be potentially manipulated for further chemical synthesis.…”