Synthesis, Redox and Spectroscopic Properties of Pterin of Molybdenum Cofactors

Colston, Kyle J.; Basu, Partha

doi:10.3390/molecules27103324

Cited by 3 publications

(2 citation statements)

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“…However, it has not yet been achieved, although the chemical synthesis of Moco’s precursor, cPMP, has been successful [ 61 ]. For a recent review, see Colston and Basu [ 62 ] in this Special Issue. In parallel to these achievements, another very active field of research has developed to reproduce the reactions catalyzed by Mo enzymes in vitro.…”

Section: History Of Mocomentioning

confidence: 99%

The History of the Molybdenum Cofactor—A Personal View

Mendel

2022

Molecules

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The transition element molybdenum (Mo) is an essential micronutrient for plants, animals, and microorganisms, where it forms part of the active center of Mo enzymes. To gain biological activity in the cell, Mo has to be complexed by a pterin scaffold to form the molybdenum cofactor (Moco). Mo enzymes and Moco are found in all kingdoms of life, where they perform vital transformations in the metabolism of nitrogen, sulfur, and carbon compounds. In this review, I recall the history of Moco in a personal view, starting with the genetics of Moco in the 1960s and 1970s, followed by Moco biochemistry and the description of its chemical structure in the 1980s. When I review the elucidation of Moco biosynthesis in the 1990s and the early 2000s, I do it mainly for eukaryotes, as I worked with plants, human cells, and filamentous fungi. Finally, I briefly touch upon human Moco deficiency and whether there is life without Moco.

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Section: History Of Mocomentioning

confidence: 99%

The History of the Molybdenum Cofactor—A Personal View

Mendel

2022

Molecules

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“…Pterins are ubiquitous in nature. They play several different roles in biology, including those of pigments [4], one-carbon transfer cofactors [5], and redox cofactors [6]. Some pterin derivatives can cause harmful effects and are classified as toxins [7].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Chlorination of 4-(Pentyloxy)-7-(prop-2-yn-1-yloxy)pteridin-2-amine

Correia

Wilke

Schulzke

2023

Molbank

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A new alkyne functionalized pterin derivative was synthesized through a reaction of 7-chloropterin with propargyl alcohol in the presence of sodium hydride. The purity and chemical structure of the compound was validated by NMR (1H, 13C) spectroscopy, Mass (APCI source) spectrometry, elemental analysis, and X-ray crystallography. The title compound may be further functionalized by exploiting the yne moiety, for instance, using click chemistry. The novel pterin derivative, most notably, in contrast to typical pterin behavior, is now soluble or even well soluble in almost any solvent except water.

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