Synthesis, self-assembly, and pH-responsive behavior of (photo-crosslinked) star amphiphilic triblock copolymer

Bian, Qingqing; Xiao, Yan; Zhou, Chen; Lang, Meidong

doi:10.1016/j.jcis.2012.08.076

Cited by 18 publications

(8 citation statements)

References 56 publications

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“…Recently, Lang and co-workers attempted to construct photocrosslinked micelles with pH-responsive behaviours using a photo crosslinkable pH-responsive star amphiphilic copolymer, star poly(3-caprolactone)-b-poly(2-cinnamoyloxyethyl methacrylate)-b-poly(2-(dimethylamino)ethyl methacrylate) (SPCL-b-PCEMA-b-PDMAEMA). 69 Cinnamate side groups within PCEMA blocks underwent photo-crosslinking by the photo-dimerization of cinnamate groups under 365 nm UV irradiation. The photo-crosslinking of the intermediate layer of PCEMA blocks suppressed the formation of intermicellar crosslinking and improved the micellar stability.…”

Section: Reviewmentioning

confidence: 99%

Photo-reversible dimerisation reactions and their applications in polymeric systems

2014

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Section: Reviewmentioning

confidence: 99%

Photo-reversible dimerisation reactions and their applications in polymeric systems

2014

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“…20 Several reviews describe [2 + 2] and [4 + 4] cycloaddition of the photosensitive moieties giving a cyclobutane dimer under UV exposure. The main photo-reactive chromophores include anthracene, 21 cinnamic acid, 22,23 thymine, stilbene, benzophenone, 24 dimethylmaleimide 25 and coumarin. 26,27 We focus the discussion on the coumarin group which enables both UV light-induced chain cross-linking (λ = 320 nm) and chain scission (λ = 254 nm) via photodimerization by [2 + 2] cycloaddition and photocleavage of the chromophore, respectively.…”

Section: Introductionmentioning

confidence: 99%

Photodimerization as an alternative to photocrosslinking of nanoparticles: proof of concept with amphiphilic linear polyoxazoline bearing coumarin unit

et al. 2015

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International audiencePhotosensitive amphiphilic linear polyoxazolines (CoumC 11-POx n) bearing alkyl chain decorated by a UV-active coumarin end group have been synthesized by cationic ring-opening polymerization (CROP). Using DLS and DOSY NMR experiments, their self-assemblies in water were compared with those of homologous photo-unreactiveamphiphilic polyoxazolines (C m-POx n). In both cases, spherical nanoparticles with D H-values around 10 nm were observed. The CoumC 11-POx n nanoparticles were illuminated upon 300 nm inducing the photo-dimerization of the coumarin units located in theinnercompartment of the nanoparticles. Finally, the pros and the cons of the photo-dimerization of linear copolymersrelated to the photo-crosslinking of graft copolymerswere discussed

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“…By all these methods scientists are trying to significantly get better the applicability of copolymers in different fields, mainly drug delivery and medicine. In this view, one of the important achievements is associated to the decrease of toxic effects or civilizing the stability, which is highly reported in the literature [20][21][22]. It is notable to point out that sometimes copolymers with a certain desired structure are impossible to be synthesized only by a single polymerization technique.…”

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confidence: 99%

Applications of Copolymeric Nanoparticles in Drug Delivery Systems

Danafar

2016

Drug Res (Stuttg)

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Nanoparticles have outstanding compensate compared with other drug carriers, as a result of their small particle size and bulky and changeable surface. Recently, block copolymers have get imaginary movement on the continuing research in the area of drug delivery technology, because of their potential to afford a biomaterial having an extensive series of amphiphilic personality, in addition to targeting the drugs to specific position. Block copolymers are prepared up of blocks of different polymerized monomers. Between the block copolymers, amphiphilic block copolymers can self-assemble to form nano-sized vehicles, for example micelles, liposomes, polymerases and hydrogels in aqueous or non-aqueous media. This review evaluated the synthesis, construction, and major applications of amphiphilic block copolymer and analogous vehicles in order to provide an overview of the present features of functionalized block copolymers for drug delivery applications.

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Synthesis, self-assembly, and pH-responsive behavior of (photo-crosslinked) star amphiphilic triblock copolymer

Cited by 18 publications

References 56 publications

Photo-reversible dimerisation reactions and their applications in polymeric systems

Photo-reversible dimerisation reactions and their applications in polymeric systems

Photodimerization as an alternative to photocrosslinking of nanoparticles: proof of concept with amphiphilic linear polyoxazoline bearing coumarin unit

Applications of Copolymeric Nanoparticles in Drug Delivery Systems

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