Synthesis, separation and N.M.R. spectra of three double bond isomers of leukotriene a methyl ester

Comparison of measured and calculated lipophilicity of substituted aurones and related compounds

“…During the past decades numerous biological activities have been published such as the inhibition of platelet aggregation, analgetic, antiasthmatic, anti-inflammatory, antiallergic, antihyperlipidemic and coronary dilation effects [13][14][15][16][17][18]. Recently, limited cytotoxic effect of various aurones has also been reported [19].…”

The conformational analysis of leukotriene D4 in aqueous solution based on high-field nuclear magnetic resonance measurements

“…It could also lead to a better understanding of the structure-activity relationships (21,22) and of the interaction of LTD, with its specific receptor. Some nmr studies have been reported on derivatives of leukotrienes (23)(24)(25)(26) and the deprotected LTD, in methanol solution (26), but only LTB, has been studied in an aqueous system (27 small amount of material available and its stability are responsible for the scarcity of these important studies, and the nature of these derivatives makes it nearly impossible to obtain crystals suitable for X-ray analysis. Hence we have carried out an extensive proton nmr investigation of LTD, in aqueous solution.…”