Synthesis, spectral and antibacterial activity of Co(II), Ni(II) and Zn(II) complexes with 2‐hydroxy‐benzoic acid(3,4‐dihydro‐2H‐naphthalen‐1‐ylidene)‐hydrazide

Abstract

A bioactive Schiff base HL i.e. 2-hydroxy-benzoic acid(3,4-dihydro-2Hnaphthalen-1-ylidene)-hydrazide was synthesized by reacting equimolar amount of salicylic acid hydrazide and 1-tetralone. Co(II), Ni(II) and Zn(II) complexes of ligand HL was synthesized in 1:1 and 1:2 molar ratio of metal to ligand. The structure of the synthesized ligand and metal complexes was established by elemental analysis, molar conductance, magnetic susceptibility measurements, electronic, IR and EPR spectral techniques. For determining the thermal stability the TGA has been done. In DFT studies the geometries of Schiff bases and metal complexes were fully optimized with respect to the energy using the 6-31 + g(d,p) basis set. Spectral data reveal that ligand behave uninegative tridentate in ML complexes and uninegative bidentate in ML 2 complexes. On the basis of characterization octahedral geometry has been assigned for Co(II) and Ni(II) complexes, while tetrahedral for Zn(II) complexes. Antibacterial activity of the synthesized compounds were evaluated against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Xanthomonas campestris and Pseudomonas aeruginosa and the results revealed that metal complexes show enhanced activity in comparison to free ligand.

Structure elucidation, DNA interaction, potential anticancer, molecular docking activities, and γ‐ray irradiation studies on novel mono‐ and binuclear Fe (II), Ni (II), Co (II), and Hg (II) Schiff base complexes

“…[13] Schiff base bear the cost of potential locales for biochemically dynamic make worse that are identified with intermolecular hydrogen holding and proton move equilibria. [14,15] Metal complexes have wide applications in organic, analytical, clinical, and modern disciplines. [15][16][17][18] Hydrazides (R-CO-NH-NH 2 ) and their subsidiaries are now the focus because of their massive biological applications, including antifungal, antibacterial, DNA binding, and antitumor activities.…”

“…[14,15] Metal complexes have wide applications in organic, analytical, clinical, and modern disciplines. [15][16][17][18] Hydrazides (R-CO-NH-NH 2 ) and their subsidiaries are now the focus because of their massive biological applications, including antifungal, antibacterial, DNA binding, and antitumor activities. [19][20][21][22] DNA binding is a critical step in DNA activity to design effective chemotherapeutic agents and better antitumor drugs.…”

Synthesis, Spectroscopic Characterization And Antimicrobial Evaluation of Novel Nitrogen Containing Metal Complexes

“…For long periods of time, coordination chemistry of Schiff base ligands has been the topic of great interest. These compounds are able to form coordination bonds with many metal ions via azomethine group (C=N) and other electron donor groups, so they have been used for the synthesis of metal complexes due to their easy formation and strong ability to bind with metal ions [4][5][6][7][10][11][12][13] and their ability to form stable complexes to use as model compounds in service of biologically important species [12][13][14] where the nitrogen atom of azomethine group may be participated in the formation of constituents and interferes in normal cell processes so the (C=N) bond in azomethine derivatives is essential for biological activities [1,15] as antitumor, antimicrobial agents (antifungal, antibacterial, antiviral and antiparasitic agents) and other biological performances [15]. These compounds have also played a great role in the chemistry development [2,3,5,6,11,16].…”

“…Their bioactivity may be due to the presence of multi-coordination centers and having ability to form stable chelates with essential metal ions, which the organisms require in their metabolism. Usually include the biological interactions necessary for life processes [12]. In the view of the aforementioned applications, herein, we report the synthesis and spectroscopic characterization of Mn(II), Co(II) and Cu(II) complexes with the ligand (L).…”

Synthesis, Characterization, DFT of novel, symmetrical, N/O-donor tetradentate Schiff’s base, its Co(II), Ni(II), Cu(II), Zn(II) complexes and their in-vitro human pathogenic antibacterial activity

“…analytical, chemical, industrial, biological and clinical etc. [2][3][4][5][6][7][8][9][10][11][12][13][14]. Schiff's bases and their metal complexes are also used for catalyzing different reactions viz.…”