Synthesis, Spectral, and Antimicrobial Studies of 1‐Butyl‐3‐substituted‐4‐(2‐aryl‐1H‐indol‐3‐yl)‐2‐azetidinones.

Abstract

Ketene generated from acylation reagent (II) adds on indolyl Schiff's base (I) to afford title compounds (III). The reaction takes place via concerted trans [2 + 2] thermal cycloaddition; the trans β-lactam isomers are formed stereospecifically in the case of chloroacetyl chloride. All products are screened for their antibacterial and antifungal activities. Promising results are observed for (IIIa) and (IIId). -(PATHAK*, V. N.; GUPTA, R.; GARG, M.; Heteroat. Chem. 15 (2004) 7, 494-501; Dep. Chem., Univ. Rajasthan, Jaipur 302 004, India; Eng.) -H. Haber 13-122