Synthesis, spectral and antimicrobial studies of diorganotin(IV)3(2′‐hydroxyphenyl)‐5‐(4‐substituted phenyl) pyrazolinates

Abstract

pyrazoline {where X = H (a); CH 3 (b); OCH 3 (c); Cl (d) and R = Me, Pr n and Ph}] have been synthesized by the reaction of R 2 SnCl 2 with sodium salt of pyrazolines in 1 : 2 molar ratio, in anhydrous benzene. These newly synthesized derivatives have been characterized by elemental analysis (C, H, N, Cl and Sn), molecular weight measurement as well as spectral [IR and multinuclear NMR ( 1 H, 13 C and 119 Sn)] studies. The bidentate behaviour of the pyrazoline ligands was confirmed by IR, 1 H and 13 C NMR spectral data. A distorted trans-octahedral structure around tin(IV) atom for R 2 Sn(C 15 H 12 N 2 OX) 2 has been suggested. The free pyrazoline and diorganotin(IV) dipyrazolinates have also been screened for their antibacterial and antifungal activities. Some diorganotin(IV) dipyrazolinates exhibit higher antibacterial and antifungal effect than free ligand and some of the antibiotics.

Synthesis, spectral and biological investigations of 5(2′-hydroxyphenyl)-3-(4-substituted-phenyl) pyrazolinates of cobalt(II) and their addition complexes with N, P donor ligands

“…Similar types of ligands have been used to prepare complexes of cobalt, copper and nickel [18]. The synthesis, spectral and antimicrobial studies of diorganotin(IV)3(2 0 -hydroxyphenyl)-5-(4-substituted phenyl)pyrazolinates, triorganotin(IV)3(2 0 -hydroxyphenyl)-5-(4-substituted phenyl)pyrazolinates and chlorodiorganotin(IV)3(2 0 -hydroxyphenyl)-5-(4-substituted phenyl) pyrazolinates have been carried out [19][20][21]. In continuation of our work [22] on synthesis, spectral and antimicrobial investigations of iron(III)5(2 0 -hydroxyphenyl)-3-(4-x-phenyl)pyrazoline complexes and their addition complexes with N and P donor ligands [23], we synthesized cobalt(II)5(2 0 -hydroxyphenyl)-3-(4-substituted-phenyl)pyrazoline complexes [here substituted groups are -H, -Cl, -CH 3 , -OCH 3 ] and their addition complexes with N and P donor ligands, i.e.…”

Synthesis, structure and thermokinetic studies on perchlorate salts of metal complexes containing a formamidine-type ligand

“…Many show remarkable biological activity [7][8][9][10][11][12][13]. Pyrazole-functionalized silica is applied for quantitative extraction and elimination of Pb II from natural water [14], while trinitropyrazole derivatives were considered as potential candidates for high-energy density materials [15].…”

Synthetic, structural and biological studies of organotin(IV) complexes of schiff bases derived from pyrrol-2-carboxaldehyde

“…At the present time, the industrial uses of non-toxic organotin compounds (R 2 SnX 2 and RSnX 3 types) account for almost two-thirds of the total world consumption, although the other major use of these derivatives as selective biocides and pesticides (RSnX 3 ) has increased rapidly in recent years [2][3][4][5].…”