Synthesis, Spectral and Biological Studies of Complexes with Bidentate Azodye Ligand Derived from Resorcinol and 1-Amino-2-Naphthol-4-Sulphonic Acid

Vidya, V.G.; Sadasivan, V.; Meena, Sher Singh; Bhatt, Pramod

doi:10.13005/ojc/340105

Cited by 12 publications

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Section: Introductionmentioning

confidence: 99%

“…16,17 Similarly, resorcinol (1,3-dihydroxybenzene) is ascribed as one of the azo dyes which readily form stable complexes with most of the transition-metal ions. 19 Selective deprotonation of resorcinol (reso) achieved by mixing equimolar with NaOH monitors the site of complexation, leading to the formation of complexes. 20,21 Modification of the surface of a working electrode usually improves its electrochemical performance by improving its compatibility, electron conductivity, mechanical properties, surface area, and control of the physicochemical nature of the electrode/solution interface.…”

Section: Introductionmentioning

confidence: 99%

“…Transition-metal complexes have many unique proprieties such as highly accessible surface area, high chemical stability, and excellent electrocatalytic activity. Therefore, they have been widely applied in the fabrication of electrochemical sensors. , Researchers in the field of coordination chemistry have been drawn toward 1,10-phenanthroline (phen) because it interacts with metal ions via the nitrogen atom it contains, favoring the formation of metal complexes. , Similarly, resorcinol (1,3-dihydroxybenzene) is ascribed as one of the azo dyes which readily form stable complexes with most of the transition-metal ions . Selective deprotonation of resorcinol (reso) achieved by mixing equimolar with NaOH monitors the site of complexation, leading to the formation of complexes. , …”

Section: Introductionmentioning

confidence: 99%

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Characterization and Application of a Synthesized Novel Poly(chlorobis(1,10-phenanthroline)resorcinolcobalt(II) chloride)-Modified Glassy Carbon Electrode for Selective Voltammetric Determination of Cefadroxil in Pharmaceutical Formulations, Human Urine, and Blood Serum Samples

et al. 2023

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Cefadroxil belongs to the β-lactam antibiotics, mainly used for the treatment of various bacterial infections, caused by Gram-positive and Gram-negative bacteria. However, it is also encountering serious bacterial resistance, necessitating continuous monitoring of its level in pharmaceutical and biological samples. This study presents a selective, accurate, and precise square-wave voltammetric method based on a novel poly(chlorobis(1,10-phenanthroline)resorcinolcobalt(II)chloride)-modified glassy carbon electrode (poly(CP 2 RCoC)/GCE) for determination of cefadroxil (CDL). UV− vis spectroscopy, FT-IR spectroscopy, metal and halide estimation, CHN elemental analysis, and electrolytic conductivity measurement results confirmed the synthesis of the title complex modifier. Electrode characterization results revealed modification of the surface of the electrode by an electroactive and a conductive polymer film (poly(CP 2 RCoC)/GCE), leading to an improved effective electrode surface area. In contrast to the bare electrode, the appearance of an irreversible oxidative peak at a much reduced potential with a 7-fold current enhancement at poly(CP 2 RCoC)/GCE showed the catalytic effect of the modifier toward oxidation of CDL. The square-wave voltammetric current response of poly(CP 2 RCoC)/ GCE showed a linear dependence on the concentration of CDL in the range of 1 × 10 −7 −3.0 × 10 −4 M with a detection limit of 4.3 × 10 −9 . The CDL level in the selected two tablet brands was in the range of 97.25−100.00% of their labeled values. The spike recovery results in tablet, human blood serum, and urine samples were 98.85−101.30, 99.20−100.39, and 98.10−99.99%, respectively. Interference recovery results with a less than 4.74% error, lower LoD, and wider dynamic range than the previously reported methods validated the potential applicability of the present method with excellent accuracy and sensitivity based on the novel mixed-ligand complex-modified GCE (poly(CP 2 RCoC)/GCE) for determination of CDL in various real samples with a complex matrix.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Characterization and Application of a Synthesized Novel Poly(chlorobis(1,10-phenanthroline)resorcinolcobalt(II) chloride)-Modified Glassy Carbon Electrode for Selective Voltammetric Determination of Cefadroxil in Pharmaceutical Formulations, Human Urine, and Blood Serum Samples

et al. 2023

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Synthesis, Characterization, Analytical and Cytotoxic Studies of N,N′‐Bis(2‐Hydroxynaphthylidene)‐4‐chlorophenyl Methanediamine and Its Co(II), Ni(II) and Cu(II) Complexes

Amala¹,

Santhi²,

Subashini³

2018

ChemistrySelect

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The present study involves one pot synthesis of a novel Schiff base derived from 2‐hydroxy‐1‐naphthaldehyde. Further the Schiff base is used for metal complex preparation. All synthesized compounds are characterized by various spectral and analytical studies. Stoichiometry of the complexes is confirmed by Job's plot method. Of the three complexes, Co(II) complex is found to be the most stable one through UV/Vis titrations and Benesi‐Hildebrand equation. Redox property of the complexes ascertained from CV(Cyclic Voltammetry) confirms catalytic application of the complexes; while fluorescence property of the complexes and the Schiff base indicates chemosensor application of the Schiff base. Both the Schiff base and the complexes are screened against bacterial and fungal pathogens. MIC (Minimum Inhibitory Concentration) studies of the Schiff base and the cobalt complex over Staphylococcus aureus disclose the MIC value as 25 ppm. Cu(II) complex is found to have cytotoxicity against breast cancer cell lines (MCF‐7).

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Synthesis of a Novel [diresorcinate‐1,10‐phenanthrolinecobalt(II)] Complex, and Potentiodynamic Fabrication of Poly(DHRPCo)/GCE for Selective Square Wave Voltammetric Determination of Procaine Penicillin G in Pharmaceutical and Biological Fluid Samples

et al. 2022

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This work presents synthesis, and characterization of a novel [diresorcinate‐1,10‐phenanthrolinecobalt(II)] (DHRPCo) complex, and potentiodynamic fabrication of poly(DHRPCo)/GCE for SWV determination of procaine penicillin G (ProPenG) in various pharmaceutical and biological samples. While UV‐Vis and FT‐IR results demonstrated stepwise synthesis of DHRPCo, the CV and EIS results evidenced modification of the surface of GCE by an electroactive polymer film that improved electrode surface area. In contrast to the peak of ProPenG at the unmodified electrode, an irreversible oxidative peak at poly(DHRPCo)/GCE with lower potential and six folds of current enhancement observed, that confirmed electrocatalytic effect of the polymer, SWV response of poly(DHRPCo)/GCE showed linear dependence on concentration of ProPenG in the range 0.1–200 μM, with LoD of 4.9 nM. Spike recovery results in various pharmaceutical and biological samples in the range 98.03–106.50 %, interference recovery in the presence of selected potential interferents at their various levels with associated errors under 3.39 %, and stability of the modifier with analysis time validated the method for determination of ProPenG. Poly(DHRPCo)/GCE was applied for determination of ProPenG in three brands of injection pharmaceutical formulation, human urine, human blood serum, and cow's milk samples. While no ProPenG was detected in the human urine, serum, and cow's milk samples, detected ProPenG in the injection powder samples was within 96.1–101.3 % of company label. The developed method showed superior performance over recently reported methods making it an excellent candidate for determination of ProPenG in real samples.

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Synthesis, Spectral and Biological Studies of Complexes with Bidentate Azodye Ligand Derived from Resorcinol and 1-Amino-2-Naphthol-4-Sulphonic Acid

Cited by 12 publications

References 0 publications

Characterization and Application of a Synthesized Novel Poly(chlorobis(1,10-phenanthroline)resorcinolcobalt(II) chloride)-Modified Glassy Carbon Electrode for Selective Voltammetric Determination of Cefadroxil in Pharmaceutical Formulations, Human Urine, and Blood Serum Samples

Characterization and Application of a Synthesized Novel Poly(chlorobis(1,10-phenanthroline)resorcinolcobalt(II) chloride)-Modified Glassy Carbon Electrode for Selective Voltammetric Determination of Cefadroxil in Pharmaceutical Formulations, Human Urine, and Blood Serum Samples

Synthesis, Characterization, Analytical and Cytotoxic Studies of N,N′‐Bis(2‐Hydroxynaphthylidene)‐4‐chlorophenyl Methanediamine and Its Co(II), Ni(II) and Cu(II) Complexes

Synthesis of a Novel [diresorcinate‐1,10‐phenanthrolinecobalt(II)] Complex, and Potentiodynamic Fabrication of Poly(DHRPCo)/GCE for Selective Square Wave Voltammetric Determination of Procaine Penicillin G in Pharmaceutical and Biological Fluid Samples

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