Synthesis, spectral characterisation, in vitro cytotoxicity, antimicrobial, antioxidant, DFT and molecular docking studies of Ru(III) complexes derived from amide-based macrocyclic ligands

“Synthesis and characterization of a novel pyridinium iodide-tagged Schiff base and its metal complexes as potential ACHN inhibitors”

“…Schiff bases containing hetero-atoms such as nitrogen, oxygen and Sulphur are of special interest due to their different ways of bonding with transition metal ions. They have been reported to exhibit a variety of biological activities due to the presence of azomethine linkage (C N) [ [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [38] , [39] , [40] , [41] ]. Transition metal complexes of Schiff bases carrying nitrogen and other donor sites have a variety of applications including biological, medicinal and analytical in addition to their vital role in organic synthesis and catalysis [ [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] ].…”

“…Taking notes, the presence of biologically active azomethine linkage (C N), pyridinium moiety, and metal ions the biological activities of the four synthesized compounds were evaluated [ [38] , [39] , [40] , [41] , [42] , [43] ]. However, we kept ourself confined within the cytotoxicity and reactive oxygen species (ROS) production activities of the synthesized compounds.…”

Benzimidazole derivatives as a new scaffold of anticancer agents: Synthesis, optical properties, crystal structure and DFT calculations

“…Benzimidazoles are well known nitrogen-containing bioactive compounds. They showed a variety of activities including anti-diabetic [ 1 ], antimicrobial [ 2 ], antifungal [ 3 ], antiviral [ 4 ], anti-cancer activity [ [5] , [6] , [7] ] (including anti breast cancer [ 8 ]) and anthelminthic [ 9 ]. Recent studies in medicinal chemistry have demonstrated them as potential drug motifs for the pharmaceutical industry [ 10 ].…”