Synthesis, spectral characterisation, morphology, biological activity and DNA cleavage studies of metal complexes with chromone Schiff base

Kavitha, P.; Reddy, Kotha Laxma

doi:10.1016/j.arabjc.2012.09.001

Cited by 42 publications

(18 citation statements)

References 39 publications

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“…Further, it increases the delocalization of π electrons over the whole chelating ring and enhances the penetration of the complexes into lipid membranes and blocking the metal‐binding sites in the enzymes of microorganisms. [ 51 ] The inhibition % value of the Co 2+ complex is lower than ligand. This is due to the large molecular weight of the Co 2+ complex, which decreases the penetration of it into the membrane.…”

Section: Resultsmentioning

confidence: 99%

Metal complexes of azo mesalamine drug: Synthesis, characterization, and their application as an inhibitor of pathogenic fungi

El-Sayed

Gaber

El-Wakeil

et al. 2021

Applied Organom Chemis

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A novel azo dye ligand, formed by the coupling of 5-aminosalycalic acid (mesalamine drug) with 2-amino pyrimidine (H 2 L) and its Co 2+ , Ni 2+ , and Cu 2 + complexes, was synthesized. The structures of ligand and its complexes have been described by elemental analysis, inductively coupled plasma (ICP), thermogravimetric analysis (TGA), magnetic moment measurements, molar conductance, ultraviolet-visible (UV-Vis), X-ray powder diffraction, infrared (IR), 1 H-nuclear magnetic resonance (NMR), 13 C NMR, and electron impact (EI) mass spectral studies. The obtained data detected that the H 2 L ligand acts as monobasic tridentate via C=N, azo nitrogen, and deprotonated OH groups. The data supported the formation of 1:2 (M:L) for Co 2+ complex, while Ni 2+ and Cu 2+ gave 1:1 (M:L) complexes mononuclear formulation. The Co 2+ and Ni 2+ complexes have octahedral structures, while Cu 2+ complex has tetrahedral geometry. The ligand and its Co 2+ , Ni 2+ , and Cu 2+ complexes were applied as an antifungal against a set of root rot-associated soil-born phytopathogenic fungi and compared with the effect of Hatric (recommended fungicide). Our findings revealed that the metal complexes exhibited greater antifungal activity than the parent ligand. The Cu 2+ complex was found to be the most effective compound.The effect of Hatric and Cu 2+ complex on structural alterations of Fusarium semitectum was studied by scanning electron microscopy (SEM).

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Section: Resultsmentioning

confidence: 99%

Metal complexes of azo mesalamine drug: Synthesis, characterization, and their application as an inhibitor of pathogenic fungi

El-Sayed

Gaber

El-Wakeil

et al. 2021

Applied Organom Chemis

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“…Results of the MTT assay for Pd(II) and Pt(II) complexes revealed a slight decrease in the viability of MCF-7 cells after 24 h compared to cells treated with the free Schiff bases ( Figure 5 b). One explanation could be that the square planar geometry of the Pd(II) and Pt(II) complexes allows them to interact with the secondary structure of DNA, potentially even inhibiting the replication of DNA [ 43 ]. Moreover, it has been reported that the antitumor activity of such complexes probably involves the inhibition of ribonucleotide reductase, which converts ribonucleotides to deoxyribonucleotides, leading to changes in genetic material [ 44 ].…”

Section: Resultsmentioning

confidence: 99%

Synthesis, Characterization and Biological Activities of Biopolymeric Schiff Bases Prepared with Chitosan and Salicylaldehydes and Their Pd(II) and Pt(II) Complexes

et al. 2017

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In an attempt to enhance chitosan biological activities, biopolymeric Schiff bases of chitosan and different salicylaldehydes and their palladium(II) and platinum(II) complexes were synthesized and tested. The chemical structures of these derivatives were characterized using 1H-NMR, FTIR spectroscopy and XPRD. Thermal analysis was done through TGA/DTG-DTA. Electronic absorption spectra and surface morphologies were analyzed by SEM-EDAX. Chitosan and its derivatives were evaluated for their in vitro antimicrobial activity against two common bacterial and fungal plant pathogens Pseudomonas syringae pv. tomato and Fusarium graminearum, respectively, and for their antitumor activity against a human breast cancer cell line (MCF-7). It was found that, compared to the nonmodified chitosan, chitosan modified with Schiff bases and their complexes was highly toxic against the MCF-7 cell line and had antibacterial effects against P. syringea. However, the modified chitosan derivatives had less pronounced antifungal effects against F. graminearum compared to the nonmodified chitosan, suggesting different modes of action.

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“…Furthermore, the complexation process will induce the delocalization of p-electrons over the chelating ring and enhances the penetration of the complex into lipid membranes and blocking of the metal binding sites in the enzymes of bacteria. In addition, the metal complex influences the breath process of the cell and hence obstructs the synthesis of proteins restricting further growth of the organisms [35]. The additional factors that enhance the action are Mn-L bond length and solubility [36].…”

Section: Examining Electron Magnifying Instrument (Sem)mentioning

confidence: 99%

N,N′-Bis[2-hydroxynaphthylidene]/[2-methoxybenzylidene]amino]oxamides and their divalent manganese complexes: Isolation, spectral characterization, morphology, antibacterial and cytotoxicity against leukemia cells

Ahmed

2020

Open Chemistry

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AbstractManganese(ii) complexes of oxalic dihydrazones {N,N′-bis[2-hydroxynaphthylidene]amino]oxamide (BHO) and N,N′-bis[2-methoxybenzylidene]amino]oxamide (BMO)} have been synthesized by a general methodology. Hydrazone ligands (BHO and BMO) were obtained by the condensation of oxalic dihydrazide with 2-hydroxynaphthalene-1-carbaldehyde and 2-methoxybenzaldehyde. From the data obtained from the spectral (mass, IR, 1H-NMR, UV-Vis, ESR), magnetic and thermal measurements in addition to the elemental analyses (CHNM), the structures of ligands and their complexes have been determined. The scanning electron microscope (SEM) was used to characterize the morphology of the complex surface. The ligands coordinated with the metal center in a bi-dentate way forming binuclear Mn–BHO and mononuclear Mn–BMO complexes. The manganese complexes are proposed to have octahedral stereochemistry. The ligands and manganese(ii) complexes have been assessed for their antibacterial and antileukemia activities. The proliferation hindrance for the free ligands was enhanced upon coordination with the manganese(ii) ions.

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Synthesis, spectral characterisation, morphology, biological activity and DNA cleavage studies of metal complexes with chromone Schiff base

Cited by 42 publications

References 39 publications

Metal complexes of azo mesalamine drug: Synthesis, characterization, and their application as an inhibitor of pathogenic fungi

Metal complexes of azo mesalamine drug: Synthesis, characterization, and their application as an inhibitor of pathogenic fungi

Synthesis, Characterization and Biological Activities of Biopolymeric Schiff Bases Prepared with Chitosan and Salicylaldehydes and Their Pd(II) and Pt(II) Complexes

N,N′-Bis[2-hydroxynaphthylidene]/[2-methoxybenzylidene]amino]oxamides and their divalent manganese complexes: Isolation, spectral characterization, morphology, antibacterial and cytotoxicity against leukemia cells

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