Synthesis, spectral characterization and biological activity of Zn(II) complex with 2′-[1-(2-hydroxyphenyl)ethylidene]benzenesulfanohydrazide

Gwaram, Nura Suleiman; Musalam, Laila; Ali, Hapipah Mohd; Abdulla, Mahmood Ameen; Shaker, Shayma A.

doi:10.1016/j.arabjc.2012.01.002

Cited by 8 publications

(15 citation statements)

References 27 publications

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“…The histopathological results revealed the protection of gastric mucosa and absence or reduction of edema and leukocyte in ltration into the subcutaneous layer of gastric wall of rats fed with γ-mangostin along with absolute alcohol. Our ndings corroborated the studies reporting the reduction of neutrophil in ltration with edema into gastric lesion encouraging the prevention gastric mucosal damage in rats upon administration of plants extracts (Kadir et al 2014;Gwaram et al 2016;Salga et al 2017). Flattening of the gastric mucosal folds which increase the surface area, recommends that γ-mangostin applies a gastroprotective effect against absolute alcohol.…”

Section: Discussionsupporting

confidence: 89%

“…Conversely, Bax proteins are apoptotic activators involved in angiogenesis and play a critical role in tumor growth and progression (Abdulla et al 2010). The ROS scavenging in gastric tissues by anti-oxidative enzymes namely superoxide dismutase (SOD) and catalase (CAT) prevents the production of gastric ulcers (Wong et al 2013;Gwaram et al 2016;Tayeby et al 2017).…”

Section: Introductionmentioning

confidence: 99%

“…Literature review suggests that absolute alcohol-mediated gastric ulcers enhance the level of reactive oxygen species (ROS) in gastric tissues (AlRashdi et al 2012;Al Batran et al 2013;Nordin et al 2014;Salama et al 2016;Saremi et al 2019;Fahmy et al 2020). The high level of ROS is accountable for substantial injuries to vascular tissues in the stomach and intestine (Gwaram et al 2016;Tayeby et al 2017). The ROS are known for downregulation of heat shock protein 70 (HSP70) and up-regulation of proapoptotic Bcl2-associated X protein (Bax) expressions (Al-Wajeeh et al 2016;Fahmy et al 2020).…”

Section: Introductionmentioning

confidence: 99%

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Gamma (γ)-mangostin attenuated gastric ulcers induced by absolute alcohol in rats: Histological, immunohistochemical and biochemical investigation

Bradosty

Hamad

Shaikh

et al. 2021

Preprint

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Garcinia mangostana L. (Clusiaceae) principally contains gamma (γ)-mangostin, a xanthone that exhibits a wide spectrum of bioactivities. The current study was aimed to establish the gastroprotective effect of this compound in ethanol-induced gastric mucosal injuries in rats. Experimental Sprague Dawley (SD) rats (n = 30) were arbitrarily alienated into 5 groups (n = 6): negative control (10% Tween 20), ulcer control (10% Tween 20 + 5ml/kg absolute alcohol), reference control (5ml/kg absolute alcohol + 20mg/kg omeprazole), and two experimental groups (5ml/kg absolute alcohol + 10mg/kg γ-mangostin and 5ml/kg absolute alcohol + 20mg/kg γ-mangostin). After successful oral feeding, all rats were anesthetized and sacrificed. Gastro-histology highlighted severe injuries to the gastric mucosa with decrease in gastric mucosal content and gastric juice pH in ulcer control group. γ-mangostin (10 mg/kg & 20 mg/kg) showed strong gastroprotective effect by enhancing gastric mucosal content and gastric juice pH compared to the ulcer group, comparable to the omeprazole. Immuno-histochemical analysis revealed that γ-mangostin found to upregulate mucosal Hsp70 protein, and down-regulate Bax proteins. The biochemical analysis of mucosal tissue homogenate showed significant antioxidant activity with increase in SOD and CAT activities, whereas MDA was significantly decreased at p < 0.001. The histological, immuno-histochemical and biochemical analysis evidenced gastroprotective effects of γ-mangostin that are attributed to its potential to inhibit alcohol induced oxidative stress. Specifically, γ-mangostin improved histology of mucosal content and enhanced anti-oxidative enzymes (SOD & CAT) with decreasing lipid peroxidation (MDA). Furthermore dose dependent administration of γ-mangostin down-regulated expression of Bax protein and up-regulated HSP70.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Gamma (γ)-mangostin attenuated gastric ulcers induced by absolute alcohol in rats: Histological, immunohistochemical and biochemical investigation

Bradosty

Hamad

Shaikh

et al. 2021

Preprint

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“…In addition, strong absorption bands of ν (N-N) appeared at 1087 and 1072 cm −1 . Another absorption bands at 3266 and 3273 cm −1 of ν (N-H) is an evidence for formation of quinazoline ring [ 29 , 30 ]. Strong absorption bands of ν (C-O) located at 1271 and 1244 cm −1 for compounds 1 and 2, respectively [ 31 ].…”

Section: Resultsmentioning

confidence: 99%

Synthesis, Characterization, and Anticancer Activity of New Quinazoline Derivatives against MCF-7 Cells

Faraj

Zahedifard

Paydar

et al. 2014

The Scientific World Journal

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Two new synthesized and characterized quinazoline Schiff bases 1 and 2 were investigated for anticancer activity against MCF-7 human breast cancer cell line. Compounds 1 and 2 demonstrated a remarkable antiproliferative effect, with an IC50 value of 6.246 × 10−6 mol/L and 5.910 × 10−6 mol/L, respectively, after 72 hours of treatment. Most apoptosis morphological features in treated MCF-7 cells were observed by AO/PI staining. The results of cell cycle analysis indicate that compounds did not induce S and M phase arrest in cell after 24 hours of treatment. Furthermore, MCF-7 cells treated with 1 and 2 subjected to apoptosis death, as exhibited by perturbation of mitochondrial membrane potential and cytochrome c release as well as increase in ROS formation. We also found activation of caspases-3/7, -8, and -9 in compounds 1 and 2. Moreover, inhibition of NF-κB translocation in MCF-7 cells treated by compound 1 significantly exhibited the association of extrinsic apoptosis pathway. Acute toxicity results demonstrated the nontoxic nature of the compounds in mice. Our results showed significant activity towards MCF-7 cells via either intrinsic or extrinsic mitochondrial pathway and are potential candidate for further in vivo and clinical breast cancer studies.

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“…[22] Measurements of Lipid Peroxidation (MDA) Level of Stomach Homogenate MDA level glandular stomach homogenate was quantified using merchantable kits consulting to manufactural technique (Cayman Chemical Co). [23] Histological Evaluation…”

Section: Quantity Of Stomach Mucus Contentmentioning

confidence: 99%

Green Synthesis of Gold Nanoparticles Using Zingiber Officinale Rhizomes Aqueous Extract and its Gastroprotective Activity Against Ethanol-Produced Stomach Ulcer in Rodents

Shareef

Hadi

‎

et al. 2022

Cihan U Erbil SCI J

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Synthesis of gold nanoparticles exhibition wide range of bioactivities and was conventionally used for the remedy of numerous disorders. Our study aims to measure the gastroprotective effect of synthesized gold nanoparticles on absolute ethanol-induced stomach ulceration in rats. The rats were noticeably administered with two doses of gold nanoparticles (175 ppm and 350 ppm) with absolute alcohol and showed a significant improvement in the adverse effect of ethanol-produced stomach damage as confirmed by decreasing ulcer index and raising % of ulcer prevention. Increased mucus pH of stomach content reduced ulcerated portion, condensed or nonappearance of edema, and white blood cells permeation subcutaneous layer. In gastric tissue homogenate, synthesized gold nanoparticles presented a substantial increase in superoxide dismutase (SOD), catalase (CAT) actions, and a substantial lessening of malondialdehyde (MDA) amount. Besides, gold nanoparticle increases the intensity of periodic acid Schiff stained (PAS) of the gastric epithelium of the stomach. Gold nanoparticles confirmed gastro-protective effects which might be qualified to its antioxidant, increase mucus secretion, increase endogenous enzymes (SOD and CAT), and reduce MDA quantity.

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Synthesis, spectral characterization and biological activity of Zn(II) complex with 2′-[1-(2-hydroxyphenyl)ethylidene]benzenesulfanohydrazide

Cited by 8 publications

References 27 publications

Gamma (γ)-mangostin attenuated gastric ulcers induced by absolute alcohol in rats: Histological, immunohistochemical and biochemical investigation

Gamma (γ)-mangostin attenuated gastric ulcers induced by absolute alcohol in rats: Histological, immunohistochemical and biochemical investigation

Synthesis, Characterization, and Anticancer Activity of New Quinazoline Derivatives against MCF-7 Cells

Green Synthesis of Gold Nanoparticles Using Zingiber Officinale Rhizomes Aqueous Extract and its Gastroprotective Activity Against Ethanol-Produced Stomach Ulcer in Rodents

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